International Journal of Applied Science - Research and Review ISSN 2394-9988 2017 Vol. 4 No. 2:14 1 iMedPub Journals www.imedpub.com Commentary © Under License of Creative Commons Attribution 3.0 License | This artcle is available in: http://www.imedpub.com/applied-science-research-and-review/ DOI: 10.21767/2394-9988.100064 Idir Mellal*, Aziz Oukaira, Emmanuel Kengene and Ahmed Lakhssassi LIMA Laboratory, University of Quebec at Outaouais, Gatneau, Quebec, 18X 3X7, Canada *Corresponding author: Mellal Idir  idir.mellal@gmail.com LIMA Laboratory, University of Quebec at Outaouais, Gatneau, Quebec, 18X 3X7, Canada. Tel: (819) 595-3900 Citation: Mellal I, Oukaira A, Kengene E, Lakhssassi A (2017) Thermal Therapy Modalites for Cancer Treatment: A Review and Future Perspectves. Appl Sci Res Rev Vol. 4 No.2:14 over the world, of the cancer deaths and the enormous number of the new cancer cases detected each year. The WHO provides some shocking statstcs by 8.8 million dead in 2015 and it is considered as the second death cause in the USA in 2016. For this reason, research on cancer treatment remains a hot and dynamic scientfc issue to improve the existng therapies. Nowadays, thermal therapy has considerably improved. It has been used in many medical applicatons and many techniques have been developed. Divided by range of the temperature atended and the tme duraton, we can classify the thermal therapy into Diathermia, Hyperthermia, and Thermal Ablaton. The frst one elevates the temperature up to 41⁰C. It is mostly used in physiotherapy to treat rheumatc diseases as muscles and joints. Its principle is based on the use of low temperature for approximately an hour to accelerate the cell healing and Introducton For thousands of years, man used temperature for therapeutc applicatons. The efect and infuence of temperature had been early observed and used even though the understanding of the bioefect of heat was not clear, so in diferent civilizatons all over the world we can fnd many uses the heat and cold to treat some diseases including tumors. The principle of the thermal therapy is the applicaton of the heat or cold to change the cutaneous, intra- artcular or core temperature of the sof tssue. Oncology remains one of the fruitul applicaton domain of the thermal therapy. Due to the enormous number of a cancerous people over the world, the World Health Organizaton (WHO) classifes cancer as one of the deadest diseases of the last decades. In 2010, the total worldwide cost of the cancer was estmated to USD 1.16 billion, and it is on rising. Many statstcs show astronomical numbers, all Thermal Therapy Modalites for Cancer Treatment: A Review and Future Perspectves Abstract Thermal therapy is a promising treatment for many patents partcularly those with surgery intolerance. It has been used since the early age of humanity. Nowadays, the thermal therapy has proved its efcacy, especially in Oncology. In fact, the tumor ablaton using a diferent modality of heatng or cooling presents a therapeutc method to ablate the extra mass and eradicate the malignant it. The administraton of the energy is performed in various ways using an energy source. Following the level of the used temperature and the nature of the used heatng or cooling source, many modalites have been developed. Hyperthermia uses the lowest temperature among them. Other modalites use an elevated temperature to kill and destroy the tumors. These ablatve therapies are Radio Frequency Ablaton (RFA), Micro Wave Ablaton (MWA), High Intensity Focused Ultrasound (HIFU), LASER Ablaton (LA), and Cryoablaton(CA). With the purpose of doing a general state of the art of the thermal therapies applied in Oncology and enlightening their advantages and limitatons, we reviewed many recent and pertnent published works in diferent databases. We also investgated the cell destructon mechanism due to temperature. We exposed the recent advances and the limitatons of these modalites. However, to improve the quality of the treatment and increase the rate of survival, the research is stll investgatng these modalites. We discussed the future challenges and perspectves of the thermal therapies. Propositons to overpass the limitatons of some techniques were introduced. Keywords: Tumor ablaton; Hyperthermia; RFA; MWA; Cryoablaton; HIFU; Laser ablaton Received: October 24, 2017; Accepted: November 21, 2017; Published: November 28, 2017