www.ijapbc.com IJAPBC – Vol. 3(2), Apr-Jun, 2014 ISSN: 2277 - 4688 352 INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article ABSTRACT The purpose of this research work was to develop and evaluate matrix-type transdermal patches containing Ramipril with HPMC E15 and Eudragit RL100 in different ratios prepared by the solvent evaporation technique. The physicochemical compatibility of the drug and the polymers were studied by Fourier Transform Infrared (FTIR) Spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. The prepared transdermal patches were evaluated for weight variation, thickness, folding endurance, moisture loss, moisture absorption, in vitro drug release, drug release kinetics and ex v iv o permeation studies. The diffusion studies were performed by using modified Franz diffusion cells. The best formulation, F6 shows weight variation 105.9±2.71mg, thickness 0.39±0.007 mm, folding endurance 96.2 ±4.75, moisture loss 3.51 ±0.65%, moisture absorption 8.57± 2.75% and exhibited highest 94.2±1.76% of drug release in 24 hours. The formulations F6 exhibited the highest Cumulative amount of drug permeated 4760.15±29.13 μg/cm 2 in 24hr with flux of 51 .52 μg/cm 2 /hr and permeation coefficient 8.79 (cm/hr)10 -3 .Release kinetic studies revealed that the drug release from formulation F6 followed zero order release kinetics with Non-fickian diffusion mechanism. KEY WORDS: Solvent evaporation technique, Folding endurance, in-vitro drug release, ex-vivo permeation. INTRODUCTION Transdermal drug delivery systems (TDDS) are defined as self contained, discrete dosage forms which, when applied to intact skin, deliver the drug(s), through the skin, at a controlled rate to systemic circulation 1 . Transdermal delivery has many advantages over conventional modes of drug administration, as because it avoids hepatic first ‐pass metabolism, potentially decreases side effects and improves patient compliance 2 .At present, the most common form of delivery of drugs is the oral route. While this has the notable advantage of easy administration. Transdermal drug delivery system has gained popularity over the past few decades. Thus conventional drugs in the form of tablets, capsules, injectables and ointments are introduced in the body as pulses that usually produce large fluctuations of drug concentration in the blood stream and tissues and consequently unfavorable patterns of safety and efficacy 3,4 .Transdermal delivery provides an improved approach to the administration of drugs by maintaining a therapeutic constant concentration of drug in the blood for desired period of time, usually between one and seven days 5 .Transdermal drug delivery enables avoidance of gastrointestinal absorption, which is associated with pitfalls of enzymatic and pH associated deactivation. This method also allows for reduced pharmacological dosing due to the shortened metabolic pathway of the D esign, Development and Evaluation of T ransdermal Patches of Ramipril Satyabrata Bhanja 1* , BrijMohan Singh Rawat 1 , Muvvala Sudhakar 1 , Bibhuti Bhusan Panigrahi 2 . 1. D epartment of Pharmaceutics, M alla Reddy College of Pharmacy, M aisammaguda Secunderabad, Andhra Pradesh, I ndia-500014. 2. Department of Pharmaceutics, H i-T ech College of Pharmacy, Bhubaneswar, Odisha , India .