Short Review RIFM fragrance ingredient safety assessment, methyl dihydrojasmonate, CAS registry number 24851-98-7 A.M. Api a , D. Belsito b , S. Bhatia a , M. Bruze c , P. Calow d , M.L. Dagli e , W. Dekant f , A.D. Fryer g , L. Kromidas a, *, S. La Cava a , J.F. Lalko a , A. Lapczynski a , D.C. Liebler h , Y. Miyachi i , V.T. Politano a , G. Ritacco a , D. Salvito a , J. Shen a , T.W. Schultz j , I.G. Sipes k , B. Wall a , D.K. Wilcox a a Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677 USA b Member RIFM Expert Panel, Department of Dermatology, Columbia University Medical Center, 161 Fort Washington Ave., New York, NY 10032, USA c Member RIFM Expert Panel, Department of Occupational & Environmental Dermatology, Malmo University Hospital, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden d Member RIFM Expert Panel, University of Nebraska Lincoln, 230 Whittier Research Center, Lincoln NE 68583-0857 USA e Member RIFM Expert Panel, School of Veterinary Medicine and Animal Science, Department of Pathology, University of Sao Paulo, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil f Member RIFM Expert Panel, Department of Toxicology, University of Wuerzburg, Versbacher Str. 9, Würzburg 97078, Germany g Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239 USA h Member RIFM Expert Panel, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA i Member RIFM Expert Panel, Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606- 8507, Japan j Member RIFM Expert Panel, College of Veterinary Medicine, Department of Comparative Medicine, The University of Tennessee, 2407 River Dr., Knoxville, TN 37996-4500, USA k Member RIFM Expert Panel, Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Avenue, P.O. Box245050, Tucson, AZ 85724-5050, USA ARTICLE INFO Article history: Received 19 November 2014 Accepted 13 January 2015 Available online 28 January 2015 Version: 011414. This version replaces any previous versions. Name: Methyl dihydrojasmonate CAS Registry Number: 24851-98-7 Abbreviation/Definition list: 2-Box Model – a RIFM, Inc. proprietary in silico tool used to calculate fragrance air exposure concentration 97.5 th percentile – The concentration of the fragrance ingredient is obtained from examination of several thousand commercial fine fragrance formulations. The upper 97.5th percentile concentration is calculated from these data and is then used to estimate the dermal systemic exposure in ten types of the most frequently used personal care and cosmetic products. The dermal route is the major route in assessing the safety of fragrance ingredients. Further explanation of how the data were obtained and of how exposures were determined has been previously reported by Cadby et al. (2002) and Ford et al. (2000). AF – Assessment Factor DEREK – Derek nexus is an in silico tool used to identify structural alerts * Corresponding author. Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677 USA. Tel.: +201 689 8089; fax: (201) 689-8090. E-mail address: lkromidas@rifm.org(L. Kromidas). http://dx.doi.org/10.1016/j.fct.2015.01.006 0278-6915/© 2015 Elsevier Ltd. All rights reserved. Food and Chemical Toxicology 82 (2015) S114–S121 Contents lists available at ScienceDirect Food and Chemical Toxicology journal homepage: www.elsevier.com/locate/foodchemtox