International Journal of Medical Science and Clinical Invention 9(5): 6107-6115, 2022 DOI:10.18535/ijmsci/v9i05.05 https://valleyinternational.net/index.php/ijmsci 6107 International Journal of Medical Science and Clinical Invention, vol. 09, Issue 05, May 2022 Review Article, Myocarditis Associated With COVID-19 Infection and Mrna Vaccination: A Review Article Arshan Khan¹, Mohammad K. Balaw², Huma Sattar³, Yash Garg 4 , Freny Sebastian¹, Chris Agyingi 5 , Hardik Fichadiya 6 , Muhammad Haseeb 7 1 Department of Internal Medicine, Ascension St. John hospital, Detroit, Michigan, USA 2 Faculty of Medicine, Hashemite University · Zarqa, JOR 3 Department of Internal Medicine, Sharif medical and dental college, Lahore, PAK 4 Department of Internal Medicine, Wyckoff Heights Medical Center, Brooklyn, USA 5 Department of Internal Medicine, Woodhull Medical Center · New York, USA 6 Department of Internal Medicine, Trinitas Regional Medical Center, Elizabeth 7 Department of Internal Medicine, Jinnah Hospital Lahore, PAK Email Address: arshan.khan@ascension.org Abstract: Coronavirus disease 2019 (Covid-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Initially, COVID-19 was considered a respiratory illness, but later on, it was found out that this disease can affect many organ systems. Cardiovascular manifestations of this disease include myocarditis, heart failure, myocardial infarction, and thromboembolism. Myocarditis related to COVID-19 is thought to be due to the direct viral injury and host immune response. The cases of myocarditis after the COVID-19 mRNA vaccine have been reported in the literature as well. COVID-19 myocarditis can present as chest pain, shortness of breath, acute heart failure, arrhythmia, and possibly death. The initial workup should include an electrocardiogram (ECG) and troponins if myocarditis is suspected. Further screening should be done if troponins are elevated, or the patient has ECG changes concerning myocardial damage. Noninvasive imaging that helps to diagnose COVID-19 myocarditis includes echocardiograms, computerized tomographic (CT) with contrast, and cardiac magnetic resonance imaging (CMR). An endomyocardial biopsy (EMB) can be performed if the diagnosis remains unclear. Initial treatment of COVID-19 myocarditis is mainly supportive, and intravenous immunoglobulin (IVIG) and corticosteroid may be effective, particularly in fulminant myocarditis. If the patient develops life-threatening arrhythmias or shock, advanced mechanical support is required. Early intervention is a critical factor in decreasing morbidity and mortality. Further research is needed to determine the efficacy of different treatment modalities, including IVIG and corticosteroids, in patients with COVID-19 myocarditis. Keywords: COVID-19 associated myocarditis, COVID-19 mRNA Vaccination associated myocarditis, Role of IVIG in COVID-19 myocarditis, Role of steroids in COVID-19 myocarditis Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) caused a pandemic that first emerged in Hubei, a province of China [1], and later spread to Spain, Iran, the United States of America (USA), the United Kingdom (UK) and then spread all over the world with each region having a different kind of strain. The World health organization (WHO) declared Coronavirus disease