J Surgical Case Reports and Images Copy rights@ Talar Vartanoglu Aktokmakyan et .al. Auctores Publishing – Volume 4(1)-058 www.auctoresonline.org ISSN: 2690-1897 Page 1 of 3 Clinical Characteristics of Four Medical Doctors used Chloroquine as prophylaxis with 2019 Novel Coronavirus-Infected Pneumonia Talar Vartanoglu Aktokmakyan 1 , Mehmet Alim Turgut 1a , Orkhan Valiyev 1b , Yunus Emre Aktimur 1c , Ahmet Guray Durmaz 1d , Fatih Celebi 1e 1 Department of General Surgeon, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey. Corresponding Author: Talar Vartanoglu Aktokmakyan, MD, General Surgeon, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey. Received date: January 01, 2021; Accepted date: January 23, 2021; Published date: February 13, 2021 Citation: Talar V. Aktokmakyan, Mehmet A. Turgut, Valiyev O., Yunus E. Aktimur, Ahmet G. Durmaz, Celebi F., (2021) Clinical Characteristics of Four Medical Doctors used Chloroquine as prophylaxis with 2019 Novel Coronavirus-Infected Pneumonia. J Surgical Case Reports and Images 4(1); DOI: 10.31579/2690-1897/058 Copyright: © 2021, Talar V. Aktokmakyan, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Aim: The aim of this study to report the initial experience in a General Surgery clinique with the epidemiologic investigation of the COVID-19 outbreak, clinical features, and usage of prophylaxis. Material and Methods: Descriptive cases of 4 general surgery assistants diagnosed with Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR) confirmed SARS-CoV-2 infection in Turkey from March 20 to March 30, 2020; the final follow-up date was March 31, 2020. Clinical, laboratory, and radiologic data were collected. The clinical course was summarized, including usage of Chloroquine as prophylaxis. Result: Among the 4 medical doctor patients with PCR-confirmed SARS-CoV-2 infection with the mean age of 29, all of them were male (100%), the clinical presentation was an upper respiratory tract infection in all of the patients. All patients use Chloroquine prophylactically before symptoms onset. Conclusions: Among the 4 medical doctors diagnosed with SARS-CoV-2 infection in the General Surgery Clinique in Turkey, the clinical presentation was frequently a mild respiratory tract infection with the use of Chloroquine. Keywords: chloroquine, covid-19, Prophylaxis Running Title: Detailed review of the frontline healthcare workers Introduction A novel coronavirus was identified at the end of the year 2019 in Wuhan, China [1]. A large case series of 72314, infected individuals has since refined these initial estimates in Chine to severe disease in 14% and a case fatality rate of 2.3% [2]. Patients with the illness, called coronavirus disease 2019 (COVID-19), frequently present with fever, cough, and shortness of breath within 2 to 14 days after exposure [3]. It has been reported that chloroquine and hydroxychloroquine, which are used in the treatment of malaria, can be effective in many in vitro experiments against sars, including SARS-CoV-2 [4]. Besides, preliminary results of some studies have been published that these drugs reduce the viral load in COVID patients and lead to positive results [5, 6]. Apart from the very limited data in terms of treatment, some researchers have suggested that these agents can be used in prophylaxis [7, 8]. In this study, we will examine the four general surgical assistants infected by COVID, although they use the chloroquine preparation prophylactically. Material and Methods Between March 20 and 30, 2020 four general surgical assistants infected with SARS-CoV-2 were diagnosed in Turkey, with symptoms onset from March 21 to March 31, 2020. All patients reported that they worked at the same clinic in the 14 days before illness onset. Patients were categorized according to their symptoms. All of them had abnormal computerized tomography (CT) findings. (Table). Demographics All patients (n=4) Mean Age 29(27-30) Sex Male (4/4) Comorbidity No Allergic Rhinitis 2/4 Signs and Symptoms Fever 2/4 Cough 2/4 Sore Throat 1/4 Headache 1/4 Weakness 1/4 Shortness of breath 0/4 Biochemical Parameter Mean WBC 6,27 10 3 /uL [5,2-8,6] Mean Hgb 15,2 g/dL [14,2-16,3] Mean Plt 321 10 3 /uL [285-398] Open Access Research Article Journal of Surgical Case Reports and Images Sherifa Mostafa M. Sabra* AUCTORES Globalize your Research