1 Article type: Regular article Title: Involvement of Dab1 in APP processing and -amyloid deposition in sporadic Creutzfeldt-Jakob patients. Authors: R. Gavín 1,3 , I. Ferrer 2,3 *, J.A. del Río 1,3 * Addresses 1) Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia and Department of Cell Biology, University of Barcelona, Baldiri Reixac 15-21, 08028 Barcelona, Spain. 2) Institute of Neuropathology (INP), IDIBELL-Hospital Universitari de Bellvitge, Faculty of Medicine, University of Barcelona, 08907 Hospitalet de LLobregat, Spain. 3) Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Running title: -amyloid and prion protein in CJD disease (*) Correspondence to: Prof. J.A. del Río MCN lab Institute of Bioengineering of Catalonia Baldiri and Reixac 15-20, 08028 Barcelona, Spain Tel: +34934020296 Fax: +34934020183 E-mail: jadelrio@ibec.pcb.ub.es Prof. I. Ferrer Institut de Neuropatologia Servei Anatomia Patològica IDIBELL-Hospital Universitari de Bellvitge Facultat de Medicina Universitat de Barcelona Feixa LLarga sn, 08907 Hospitalet de LLobregat, Spain Tel: +34934035808 Fax: +34934035810 E-mail: 8082ifa@gmail.com