ESI for New Journal of Chemistry S1 Supplementary Information Novel styrylpyrazole-glucosides and their dioxolo-bridged doppelgangers: synthesis and cytotoxicity Ana R. F. Carreira, a David M. Pereira, b Paula B. Andrade, b Patrícia Valentão, b Artur M. S. Silva, a Susana Santos Braga,* a Vera L. M. Silva * a a Chemistry Department, QOPNA and LAQV-REQUIMTE, University of Aveiro, 3810-193 Aveiro, Portugal b REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal Emails: sbraga@ua.pt and verasilva@ua.pt Table of Contents: 1. NMR spectra………………………………………………………………….. S3 Figure S1. 1 H NMR spectrum of compound 1d (CDCl3, 300.13 MHz)…………………... S3 Figure S2. 13 C NMR spectrum of compound 1d (CDCl3, 75.47 MHz)…………………… S3 Figure S3. 1 H NMR spectrum of compound 2a [(CD3)2CO, 500.16 MHz]……...……….. S4 Figure S4. 13 C NMR spectrum of compound 2a [(CD3)2CO, 125.77 MHz]......………….. S4 Figure S5. 1 H NMR spectrum of compound 2b [(CD3)2CO, 300.13 MHz]……...……….. S5 Figure S6. 13 C NMR spectrum of compound 2b [(CD3)2CO, 75.47 MHz]......…………… S5 Figure S7. 1 H NMR spectrum of compound 2c [(CD3)2CO, 500.16 MHz]……...……...… S6 Figure S8. 13 C NMR spectrum of compound 2c [(CD3)2CO, 75.47 MHz]......………...….. S6 Figure S9. 1 H NMR spectrum of the mixture of (E)- and (Z)-isomers of compound 2d [(CD3)2CO, 500.16 MHz]……...…………………………………………………………... S7 Figure S10. 13 C NMR spectrum of the mixture of (E)- and (Z)-isomers of compound 2d [(CD3)2CO, 125.77 MHz]......………...……………………………………………………. S7 Figure S11. 1 H NMR spectrum of compound 3a [(CD3)2CO, 500.16 MHz]……...……… S8 Figure S12. 13 C NMR spectrum of compound 3a [(CD3)2CO, 125.77 MHz]......………… S8 Figure S13. 1 H NMR spectrum of compound 3b [(CD3)2CO, 300.13 MHz]……...……… S9 Figure S14. 13 C NMR spectrum of compound 3b [(CD3)2CO, 75.47 MHz]......………….. S9 Figure S15. 1 H NMR spectrum of compound 3c [(CD3)2CO, 500.16 MHz]……...………. S10 Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2019