Accepted Manuscript Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaus- tion? Chenqi Zhao, Nathalie Amiable, Melissa Laflamme, David Marsolais, John A. Di Battista, Maria J. Fernandes, Sylvain G. Bourgoin PII: S0006-2952(19)30047-4 DOI: https://doi.org/10.1016/j.bcp.2019.02.009 Reference: BCP 13415 To appear in: Biochemical Pharmacology Received Date: 30 November 2018 Accepted Date: 8 February 2019 Please cite this article as: C. Zhao, N. Amiable, M. Laflamme, D. Marsolais, J.A. Di Battista, M.J. Fernandes, S.G. Bourgoin, Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?, Biochemical Pharmacology (2019), doi: https://doi.org/ 10.1016/j.bcp.2019.02.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.