1698 PIERS Proceedings, Stockholm, Sweden, Aug. 12–15, 2013 System Information Therapy in the Management of Pain: A Pilot Study Paolo Baron 1 , Giuseppe Bucci 1 , Alfio Rinaudo 1 , Roberto Rocco 1 , Eugenio Sclauzero 1 , and Alberto Foletti 2, 3 1 General Practictioners, Regione Friuli Venezia Giulia, Italy 2 Institute of Translational Pharmacology, National Research Council — CNR Via Fosso del Cavaliere, 100, Rome 00133, Italy 3 Deartment of Innovative Technologies University of Applied Sciences of Southern Switzerland — SUPSI Galleria 2, Manno 6928, Switzerland Abstract— Dealing with pain is an important daily part of current medical practice. Biophys- ical methods by use of medical devices (such as Med Select 729 in this trial) allows to perform very personalized treatment using endogenous signals of the patient leading to the definition of a System Information Therapy (SIT) approach. An open labeled clinical trial was designed to assess the effectiveness of a biophysical treatment compared to a common anti inflammation drug (ibuprofen) and compared to placebo. Methods: patients has been divided in three groups: Group 1 System Information Therapy patients receiving two steps of treatment by the Med Select 729 medical device: 1st step delivered with a program called regulation therapy with recording of endogenous input signals at the painful region and delivery of therapeutic output signals at systemic level by mean of an electromagnetic mattress on which the patient lied — 2nd step delivered with the program called pain therapy: recording endogenous input signals at the painful region and delivery of therapeutic output signals at the pain site, moreover a copy of therapeutic signals has been recorded on a commercial available aqueous system (Nomabit Base). Group 2 Pharmacological therapy: receiving ibuprofen 600 mg twice a day for 10 days. Group 3 Placebo group: receiving only Nomabit Base solution as placebo. A total of 66 patients was enrolled: 26 in System Information Therapy group (17 f, 9 m), 23 in the pharmacological group (11 f, 9 m); 17 in the placebo group (12 f, 5 m). Evaluation of follow up was performed by a visual analogue scale at the beginning, after one week, after one month, and after three months. After one week biophysical therapy shows similar effect than ibuprofen and after one month the statistical significance was χ 2 = 12.153 with p< 0.02. In conclusion the biophysical therapy protocol demonstrated the same effectiveness than usual pharmacological therapy with ibuprofen at first week reaching statistical significance after one month of administration and maintaining the effect at tree month. System information therapy seems, therefore, to be an effective and safe method in the management of pain in current medical practice representing a possible resource especially for patients with chronic disease and multiple comorbidities in order to reduce drug overload. 1. INTRODUCTION Practitioners has to cope daily with many kind of pain related diseases. Pain usually expresses maladaptive response to stress. Stress can be defined as a condition or state in which a perceived discrepancy between afferent stimuli and a well-defined range of allostasis activates adaptive re- sponses trying to reduce this possible discrepancy. Allostasis describe the dynamic adaptive process aimed to keep stability while coping with both internal of external challenges. Allostasis describe the dynamic adaptive process aimed to maintain the most effective condition of the whole organism at any moment: therefore it is intrinsically time varying according to different combinations of both inner and external conditions. Allostatic load is the sum of allostatic response exciding physiolog- ical attitude of the organism at a certain time. Allostatic load occur when activation of allostatic response are continuously settled [1–3]. Pain is part of almost any adaptive response in the acute diseases yielding a fastening in recovery of allostasis. Pain is part of the maladaptive responses in chronic diseases leading to a worsening of allostatic load and slowing recovery [4–6]. In this frame- work it is clear that coping with pain has to be considered not only from a symptomatic viewpoint but also from a systemic perspective [7–10]. Biophysical methods by use of electro-medical devices allows to deliver treatment using endogenous electromagnetic signals and is therefore consistent with the developing concept of personalized medicine [11, 12]. In the last decays a progressive fall