21 Available online at www.derpharmachemica.com ISSN 0975-413X CODEN (USA): PCHHAX Der Pharma Chemica, 2020, 12(6): 21-24 (http://www.derpharmachemica.com/archive.html) Study of some mixed-ligand ternary complexes of Ni (II) ion with drug dapsone as primary ligand and different amino acids as secondary ligand Damini Vishwakarma 1 , Shraddha Shukla 2 , Anupama Kashyap 3 and Anil Kumar Kashyap 4 *Corresponding author: Damini Vishwakarma, Department of chemistry, Govt. V. Y. T. PG Autonomous College, Durg E-mail: ltodorov@pharmfac.mu-sofia.bg ABSTRACT Mixed -ligand ternary complexes of Ni (II) ion with drug dapsone and different amino acids are synthesized and characterized. In this process drug dapsone is used as primary ligand and different amino acids such as prolein, glycine, alanine, histidin, arginine, threonine, valein, methionine, tryptophan and lysine are used as secondary ligand. The prepared ternary complexes were characterized by elemental analysis, UV-Visible and IR spectral analysis as well as magnetic measurements. The general formula [Ni(dap)L]. xH 2 O were found for the ternary complexes, where L is amino acid and x is the number of coordinated water molecules. From the analytical and spectral data, the stoichiometry has been found to be 1:1:1 for the complexes. Keywords: Dapsone, Spectral analysis, Mixed-ligand complexes, Magnetic measurements. INTRODUCTION Mixed ligand complex formation is widely in systems where metal ion and two or more ligands are present [1]. They also play an important role in catalytic centre of mtalloenzymes and metal activated enzymes. Thus, investigation and the interaction between various transition metals and amino acids and their ternary complexes can be used as metalloenzyme models [2]. Amino acids with one or more than one coordination site along with different functional group has a significant role in complexes of drugs play an important role in numerous chemical and biological systems [3]. The role of transition metal ions and their complexes are involved in metabolism, transportation and catalytic procceses in systems [4]. Nickel catalyse reactions proceed through cycles involving the nickel in various oxidation states. The catalytic applications of nickel complexes have been explained extensively [5-12]. The main attempt of this work is to know the proper mechanism of action of drugs and lower side effects [13]. The complexes of drugs has higher efficacy than potent drug [14]. Dapsone is antileprotic drug [15-16], nearly water insoluble and very weakly basic drug. It is used in the treatment of dermatitis herpetiformis, rheumatic and connective tissue disorders [17]. The literature survey shows that there is very limited work of ternary complexes of transition metals like Ni (II) ion with drug and different amino acids have reported. Hence the present paper deals with the systematic study of Ni (II) complexes with drug dapsone as primary ligand and different amino acids as secondary ligand. Structure of dapson