Sharadha M et al., Int. J. Res. Pharm. Sci., 11(1), 221-232 ORIGINAL ARTICLE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps Development and evaluation of medicated cosmetic cream to produce triple effect on skin for the treatment of uneven skin tone Sharadha M, D V Gowda * , Famna Roohi N K Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru - 570015, India Article History: Received on: 02.07.2019 Revised on: 15.10.2019 Accepted on: 21.10.2019 Keywords: Triple effect, Medicated cosmetic cream, Diffusion studies, Acute dermal toxicity ABSTRACT Combinations of drugs are available in the market only to produce a single effect. To overcome this, a combination of three drugs namely α-arbutin, glu- tathione, and grape seed extract, are used to beneϑit the triple effect on the skin. The set forth study to formulate and evaluate medicated cosmetic cream in an effective curative strategy for derma to produce a triple effect. Medicated cosmetic cream containing triple bioactive agents formulated by the O/W dis- persion method. Fourier transform infrared (FT-IR) and differential scan- ning calorimetry (DSC) was carried out for characterization. The formulated cream assessed for physical appearance, homogeneity, pH, viscosity, parti- cle size analysis, spreadability, percentage yield, drug content, diffusion stud- ies, release kinetics, acute dermal toxicity studies, and short-term stability studies. FT-IR and DSC studies revealed that no chemical interaction existed between the drug and excipients used. The optimized formula A5 revealed to be off white, semisolid, pleasant odor, smooth & slippery texture, non-greasy smear, easy to remove, and homogenous. The A5 cream exhibited a pH of 5.89, Viscosity of 1597.73 CPS, Spreadability of 20.86 g.cm/sec., the Particle size of 0.237%, Percentage yield of 98.8%, Drug content of 99.22 at 289 nm, 99.75 at 200 nm and 100.1 at 286 nm. The optimized cream demonstrated prolonged drug release 94.41% at 289 nm, 92.68 at 200 nm, and 92.78 at 286 nm up to 12 hrs. The optimized cream remained stable after the heating-cooling cycle at 4 ◦ C, 45 ◦ C and at room temperature. Furthermore, acute dermal toxicity stud- ies showed the optimized formulation to be non-irritant, with no erythema, and no edema. The present study signiϑied that the multiple combinations showed a better synergistic effect, superior efϑicacy, and multiple activities that resulted in the best, smooth, and stable medicated cosmetic cream. * Corresponding Author Name: D V Gowda Phone: +91 9663162455 Email: dvgowda@jssuni.edu.in ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v11i1.1811 Production and Hosted by Pharmascope.org © 2020 | All rights reserved. INTRODUCTION Humans are always fascinated by the color and appearance of the skin. To look stunning and beau- tiful is a natural aspiration. Men and women always harbor a hidden desire to change their skin appear- ance. This increased awareness of looking good has also brought in more sensitivity to problems of the skin, especially the face. The ability to alter the state- ment of pigment and wrinkle content in the skin, to advance an even-looking skin tone and a pro- gressively young appearance, profoundly wanted in the present Society. Indians are seeing a change in outlook from conventional techniques for utiliz- © International Journal of Research in Pharmaceutical Sciences 221