Gowda D V et al., Int. J. Res. Pharm. Sci., 2020, 11(1), 1055-1066 REVIEW ARTICLE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES Published by JK Welfare & Pharmascope Foundation Journal Home Page: www.pharmascope.org/ijrps A Comprehensive review on Dendrimers in current advanced Drug delivery Chirag M, Gowda D V * , Sathish Babu, Famna Roohi N K Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India Article History: Received on: 13.07.2019 Revised on: 11.10.2019 Accepted on: 26.10.2019 Keywords: Dendrimers, Arborols, Cascade, nano polymeric structure ABSTRACT In this particular review, it is been noted that Dendrimers are novel three- dimensional globular nano-polymeric structure; having multiple functional groups on the surface enhances their function. Synonymous terms for den- drimer include arborols and cascade molecules. The importance of den- drimers in a large variety of ϑields has been detected, where the various types of dendrimers helps in various ϑields of drug delivery with the different types of dendrimers with the generation. Hence the dendrimer gains more attention from researchers among various nano-materials. Convenient synthesis of the structure makes them as a good nano-material for drug delivery. In recent, dendrimers showed their activity in different drug delivery systems having properties like cancer targeting, anti-bacterial, ocular drug delivery, etc.. The future direction about the dendrimers are been discussed. The present review is focused on types of dendrimers like Polypropylene Imine dendrimer (PPI), Poly(amidoamine) dendrimers (PAMAM), Poly-l-lysine dendrimers, Type of Frechet’s dendrimer, Core-shell tecto dendrimers, Chiral dendrimers, Liq- uid crystalline dendrimers, Peptide dendrimers, Multiple antigen peptide dendrimers, Glyco-dendrimers, Hybrid dendrimers, Polyester dendrimers in which among these type of dendrimers, the Polypropylene Imine dendrimer (PPI) and Poly(amidoamine) dendrimers are found to be good carriers for var- ious targeting site, Dendrimers are synthesized through various methods like Divergent method, Convergent method, Hyper cores and branched monomer growth method, Double exponential growth method, Click chemistry method, recent advances in dendrimers are used in the Anti-cancer delivery, Anti- bacterial delivery, oral route delivery, pulmonary drug delivery, transdermal drug delivery, ocular delivery, and targeted drug delivery the safety aspects, and future strategies are also been discussed in the below article. * Corresponding Author Name: Gowda D V Phone: +91-9663162455 Email: dvgowda@jssuni.edu.in ISSN: 0975-7538 DOI: https://doi.org/10.26452/ijrps.v11i1.1936 Production and Hosted by Pharmascope.org © 2020 | All rights reserved. INTRODUCTION Dendrimers are nano-molecule, tree-like branched structures, which are having radially symmetric molecules. (Campbell et al., 2007) Dendrimers are known as single disperse macromolecules, which are having symmetric branching units around a core. These nano-molecules were ϑirst exposed by Fritz Vogtle in 1978. Arborols are called as a second group of the synthesized macromolecules. Cascade molecule is another name of the dendrimer, but the cascade term is not used as much as the den- drimer term. (Newkome, 1985; Tomalia, 1985) Size, © International Journal of Research in Pharmaceutical Sciences 1055