~ 710 ~ Journal of Entomology and Zoology Studies 2018; 6(3): 710-713 E-ISSN: 2320-7078 P-ISSN: 2349-6800 JEZS 2018; 6(3): 710-713 © 2018 JEZS Received: 10-03-2018 Accepted: 11-04-2018 M Islam Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India DC Pathak Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India S Das Department of Veterinary Microbiology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India T Rahman Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India S Sarma Department of Veterinary Biochemistry, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India R Borgohaign North East Regional Disease Diagnosis Laboratory, Government of Assam, Khanapara, Guwahati, Assam, India Correspondence M Islam Department of Veterinary Pathology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, India Hematological and biochemical alterations in goats due to paste des petits ruminan t’s viral infection M Islam, DC Pathak, S Das, T Rahman, S Sarma and R Borgohaign Abstract The present study was conducted to evaluate the different hematological and serum biochemical alterations in naturally infected Paste des petits ruminant’s viral (PPRV) infection in goats of Assam. A total of 26 whole blood samples from infected Assam Local goats and 10 blood samples from healthy local goats of Assam were collected and analyzed. All the test results were subjected to analyze the Analysis of Variance (ANOVA). Analysis of Variance showed significant increase in total erythrocyte count (P<0.05), hemoglobin (P<0.01), packed cell volume (P<0.01) and significant decrease in total leucocytes count (P<0.01) in PPRV infected goats in compared with healthy goats. Lymphopenia was constant finding in differential leucocytes count in infected goats in compared with healthy goats. Biochemical study revealed significant decrease in serum protein (P<0.01) and significant increase in serum potassium level (P<0.01), with non-significant increase of serum sodium level in infected goats in compared with apparently healthy goats. This is due to nephritic damage which cause in permeability of glomerular capillary wall. Keywords: Biochemical, C-ELISA, Hematology, PPRV, ANOVA 1. Introduction India is a vast country with a population of 137.17 million goats and 65.06 million sheep, of which Assam shares 6.16 million and 0.51 million goats and sheep respectively [1] . In India sheep and goat play a major role in sustainable agricultural and employment generation [2, 3] . Sheep and goat husbandry is popular in small, marginal and landless farmers. As in Assam 52% of farmers depend on agriculture, so sheep and goat husbandry play a major role in their livelihood and fulfilling the daily requirements of protein in the form of milk and meat along with high quality manure. Sheep and goat husbandry is frequently affected by some infectious diseases, which may occur in epidemic form. Some of the commonly encountered infectious diseases are enterotoxaemia, Paste des petits ruminants, foot and mouth disease, bluetongue, haemonchosis, mastitis etc. Out of these diseases, PPR is a newly introduced disease to NE India including Assam. Peste des petits ruminants is a disease of small ruminants specially in sheep and goats. It is a highly contagious and infectious with an economically important disease which causes high morbidity and mortality rate [4] . The disease was first described in West Africa [5] . In India, the disease was first reported in 1987 in the village of Arasur located in the villapurum district of Tamil Nadu [6] . The disease is caused by Peste des petits ruminant’s virus, under the genus Morbillivirus of the family Paramyxoviridae. The disease is characterized by pyrexia, dyspnoea, pneumonia, mucopurulent occulo-nasal discharge, errosive rhinitis, necrotic ulcers in mouth, on dental pad, tongue and lips. In early stages there is stomatitis followed by severe enteritis and diarrhea [7] . Since, the virus is a lymphotropic and epitheliotropic in nature [8] . So the present investigation was carried out to evaluate the different parameters of haematological and biochemical alteration of the disease in the naturally infected local goats of Assam. 2. Materials and Methods 2.1 Ethical approval Present study was conducted after approved by the Institutional Animal Ethics Committee of College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati, Assam, and India. The approval number is No. 770/ac/CPCSEA/FVSc/AAU/IAEC/14-15/261 Dated. 20/06/1014.