SYSTEMATIC REVIEW Early clinical performance of resin cements in glass-ceramic posterior restorations in adult vital teeth: A systematic review and meta-analysis Samantha Jéssica Lopes Sousa, a Deborah Lousan do Nascimento Poubel, MSD, DDS, b Liliana Vicente Melo de Lucas Rezende, MSD, DDS, PhD, c Fabiana Tolentino Almeida, MSc, DDS, PhD, d Isabela Porto de Toledo, MS, SLP, e and Fernanda Cristina Pimentel Garcia, MSD, DDS, PhD f To satisfy the esthetic and func- tional requirements in restorative dentistry, cements, cementation techniques, bonding systems, and bonded glass-ceramics have been developed and have become popular. 1 To ensure adequate resistance and es- thetics, a product is needed between the tooth and the ceramic restoration. 2 Cements are necessary to provide good marginal adaptation and for ensuring the retention of the restoration. Moreover, they also contribute to the maintenance of the porcelain margin and original color of the restoration. 2 Adhesive cementation can be achieved using resin ce- ments, 3,4 which are typically modified composite resins with a higher fluidity to improve flow during cementation. 5 Conven- tional cementation methods This work was supported by the National Council for Scientific and Technological Development (CNPq) through of the Scientific Initiation Program (ProIC/DPP/UnB). This work was presented at the Dental Conference of the University of Brasilia (UnB) annual meeting, Brasilia, Federal District, Brazil, May 2018. a Predoctoral student, Dentistry Department, Health Sciences Faculty, University of Brasilia (UnB), Brasilia, Brazil. b Doctoral student, Dentistry Department, Health Sciences Faculty, University of Brasilia (UnB), Brasilia, Brazil. c Clinical Professor, Dentistry Department, Health Sciences Faculty, University of Brasilia (UnB), Brasilia, Brazil. d Postdoctoral scholar, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada. e Doctoral student, Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia (UnB), Brasilia, Brazil. f Clinical Professor, Dentistry Department, Health Sciences Faculty, University of Brasilia, Brasilia (UnB), Brazil. ABSTRACT Statement of problem. Dentists must regularly determine the best adhesive cementation protocol for glass-ceramic restorations on posterior teeth. The authors are aware of few in vivo follow-up studies and no meta-analyses, including clinical trials, regarding this clinically relevant topic, which merits further investigation. Purpose. The purpose of this systematic review and meta-analysis was to statistically analyze the clinical performance of glass-ceramic posterior restorations by using a descriptive synthesis based on the integrity of the tooth and restoration under different cementation protocols for self-adhesive or conventional resin cements. Material and methods. The electronic databases Cochrane, LILACS, PubMed/MEDLINE, SciELO, Scopus, and Web of Science were used to identify relevant clinical trials. Nonepeer-reviewed literature searches and hand searching were performed to find additional references. Language, participant’s age, or time restrictions were not set. Restoration and tooth integrity were the 2 aspects considered for the meta-analysis. Statistical analyses were performed using a software program in which fixed or random effect models with risk ratios and 95% confidence intervals were applied. Results. Three prospective randomized or quasirandomized clinical trials, published in English from 2012 onward, were selected and statistically analyzed. The integrity of the tooth and restoration was assessed at the baseline and 1 year after the restorative intervention. The statistical analyses did not show any significant differences between the intervention and control groups in terms of the integrity of the tooth and restoration. Conclusions. This meta-analysis indicated no clinical differences in the ceramic cementation using a self-adhesive or conventional resin cement after the 1-year follow-up period because both resin cements showed adequate properties for tooth and restoration integrity. (J Prosthet Dent 2020;123:61-70) THE JOURNAL OF PROSTHETIC DENTISTRY 61