Journal of Cardiovascular Pharmacology Publish Ahead of Print DOI: 10.1097/FJC.0000000000000520 METFORMIN EXPOSURE DURING PREGNANCY AND 1 LACTATION DID NOT CAUSE VASCULAR REACTIVITY 2 ALTERATION IN ADULT MALE OFFSPRING 3 4 Daniella R. B. S. Novi, MSc 1 , Simone Forcato, MSc 1 , Camila B. 5 Vidigal, BS 1 , Guilherme H. Loiola, BS 1 , Daniela C. C Gerardin, 6 PhD 1 , Graziela S. Ceravolo, PhD 1 7 1 Department of Physiological Sciences, Biological Sciences 8 Center, State University of Londrina, Brazil. 9 10 Corresponding author: Departamento de Ciências Fisiológicas, 11 CCB-UEL-Campus Universitário, 86051-980-Londrina-PR, Brazil. 12 Tel.: 55 43 33714307; fax: 55 43 33714467. e-mail address: 13 gsceravolo@uel.br (G.S. Ceravolo). 14 Running title: Metformin developmental exposure and vascular 15 reactivity 16 Author’s disclosure: The authors report no conflicts of interest. 17 18 19 ACCEPTED Copyright Ó 2017 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.