Accepted Manuscript Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conju- gates as potential cytotoxic and DNA topoisomerase I inhibitors Manda Sathish, Sabanis Chetan Dushantrao, Shalini Nekkanti, Ramya Tokala, Soujanya Thatikonda, Yellaiah Tangella, Gunda Srinivas, Shirisha Cherukommu, Namballa Hari Krishna, Nagula Shankaraiah, Narayana Nagesh, Ahmed Kamal PII: S0968-0896(18)30996-9 DOI: https://doi.org/10.1016/j.bmc.2018.08.031 Reference: BMC 14518 To appear in: Bioorganic & Medicinal Chemistry Received Date: 23 May 2018 Revised Date: 22 August 2018 Accepted Date: 25 August 2018 Please cite this article as: Sathish, M., Chetan Dushantrao, S., Nekkanti, S., Tokala, R., Thatikonda, S., Tangella, Y., Srinivas, G., Cherukommu, S., Hari Krishna, N., Shankaraiah, N., Nagesh, N., Kamal, A., Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors, Bioorganic & Medicinal Chemistry (2018), doi: https://doi.org/10.1016/j.bmc.2018.08.031 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.