123 Pengaruh Pemberian Vitamin C Terhadap Kadar Serum LDH dan Kualitas Hidup Pasien Limfoma Non–Hodgkin Shahnaz Fathia 1* , Mediarty Syahrir 1,2 , Monika Anastasia 2 , Erial Bahar 1 1 Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Indonesia 2 RSUP Dr. Mohammad Hoesin, Palembang 3 Departemen Gizi Klinik, Fakultas Kedokteran, Uniersitas Sriwijaya, Palembang, Indonesia E-mail : shanziru@gmail.com Abstrak Limfoma Non-Hodgkin (LNH) merupakan keganasan primer limfosit yang dapat berasal dari limfosit B, limfosit T. Vitamin C berperan sebagai antioksidan didalam tubuh. Penelitian ini untuk mengetahui pengaruh pemberian vitamin C terhadap kadar serum LDH dan kualitas hidup pada pasien LNH di RSMH Palembang. Penelitian ini merupakan pilot study dengan uji klinik terbuka, dilakukan mulai Februari 2021 sampai Mei 2021. Terdapat 15 subjek penelitian (usia 18-60 tahun) diberikan suplementasi Vitamin C 2 gram perhari selama 8 minggu. Sebelum dan setelah perlakuan diperiksakan kadar LDH, serum vitamin C, mengisi kuesioner FFQ (asupan vitamin C) dan kuesioner EORTC C30 (kualitas hidup). Didapatkan penurunan kadar LDH antara sebelum dan sesudah perlakuan pada kelompok low grade (p = 0.008) dan pada kelompok high grade (p= 0,000). Didapatkan perbaikan kualitas hidup antara sebelum dan sesudah perlakuan pada kelompok low grade (p< 0,05). Didapatkan korelasi negatif kuat pada kelompok high grade antara kadar vitamin C dengan kadar LDH sebelum perlakuan (r= -0,75; p= 0,031) dan sesudah perlakuan (r= -0,819; p= 0,013). Pada kelompok high grade setelah perlakuan didapatkan korelasi positif kuat antara nutrisurvey vitamin C dengan skala fungsi (r= 0,790; p= 0,02) dan korelasi negatif kuat dengan skala gejala (r= -0,74; p= 0,03). Suplementasi vitamin C mempengaruhi penurunan kadar serum LDH pada semua stadium klinis pasien LNH dan mempengaruhi perbaikan kualitas hidup serta mempengaruhi korelasi antara kadar vitamin C dengan komponen skala gejala kualitas hidup pasien LNH stadium lanjut atau high grade di RSMH Palembang. Kata kunci: kualitas hidup, LDH, limfoma non – hodgkin, vitamin C Abstract The effect of vitamin c supplementation on serum LDH levels and quality of life of non-hodgkin lymphoma patients. Non-Hodgkin's Lymphoma (NHL) is a primary malignancy of lymphocytes that can be derived from B lymphocytes, T lymphocytes. Vitamin C plays a role as an antioxidant in the body. This study was to find out the effect of vitamin C administration on LDH serum levels and quality of life in NHL patients at RSMH Palembang. This study was a pilot study with open clinical trials, conducted from February 2021 to May 2021. There were 15 research subjects (age18- 60 years) given vitamin C supplementation 2 grams per day for 8 weeks. Before and after treatment was examined LDH levels, serum vitamin C, fill out the FFQ questionnaire (intake of vitamin C) and EORTC C30 questionnaire (quality of life). Obtained a decrease in LDH levels between before and after treatment in the low grade group (p =0.008) and in the high grade group (p= 0.000). Obtained improvement of quality of life between before and after treatment in the low grade group (p <0.05). A strong negative correlation was obtained in the high grade group between vitamin C levels and LDH levels before treatment (r= -0.75 p = 0.031) and after treatment (r= -0.819 p = 0.013). In the high grade group after treatment there was a strong positive correlation between vitamin C nutrisurvey with function scale (r = 0.790 p = 0.02) and strong negative correlation with symptom scale (r = -0.74 p = 0.03). Vitamin C supplementation decrease LDH serum levels in all clinical stages of NHL patients and improve quality of life and influence the correlation between vitamin C levels and the scale component of quality of life symptoms in advanced or high grade group of NHL patients in RSMH Palembang. Keywords: LDH, non lymphoma–hodgkin's, quality of life, vitamin c