Journal Syifa Sciences and Clinical Research (JSSCR) Volume 4 Nomor 1, 2022 Journal Homepage: http://ejurnal.ung.ac.id/index.php/jsscr, E-ISSN: 2656-9612 P-ISSN:2656-8187 DOI : https://doi.org/10.37311/jsscr.v4i1.13496 25 Evaluasi Penggunaan Antibiotika Profilaksis Operasi Digestif Laparatomi Selly Septi Fandinata 1* , Ilil Maidatuz Zulfa 2 ,Eziah Ika Lubada 3 1,2,3 Diploma III Farmasi, Akademi Farmasi Surabaya, Jl. Ketintang Madya No.81 Surabaya, Indonesia * Penulis Korespondensi. Email: sellyfandinata@akfarsurabaya.ac.id ABSTRAK Laparatomi termasuk operasi besar dan meyebabkan banyak perlukaan, sehingga resiko terjadinya infeksi luka operasi laparatomi cukup tinggi. Infeksi Luka Operasi (ILO) atau Infeksi Tempat Pembedahan (ITP). Pencegahan infeksi pasca bedah padapasien dengan operasi bersih terkontaminasi, dan beberapa operasi bersih dengan penggunaan antibiotik profilaksis. Tujuan penelitian untuk mengevaluasi penggunaan antibiotik profilaksis pada pasien operasi laparatomy di salah satu rumah sakit kota Surabaya. Metode penelitian secara deskriptif operasional dengan data retrospektif. Hasil penelitian ini didapatkan sebanyak 160 pasien usia 46-55 tahun sebesar 20,6%, jenis kelamin responden didominadi oleh jenis kelamin laki-laki 66,3%, dan diagnosa Peritonitis generalisata 46,9%. Penggunaan antibiotika profilaksis adalah golongan antibiotika sefalosporin generasi I (cefazolin) dengan dosis 1000-2000 mg, dimana sudah sesuai dengan menurut pedoman KEMENKES 2011 dan IDSA (Infectious Diseases Society of America) 2013. Kata Kunci: Antibiotika; Profilaksis; Laparatomi; Kesesuaian Diterima: 31-01-2022 Disetujui: 10-02-2022 Online: 25-02-2022 ABSTRACT Laparotomy is a major operation and causes a lot of injuries, so the risk of infection of the laparotomy surgery wound is quite high. Surgical Site Infection (ILO) or Surgical Site Infection (ITP). Prevention of postoperative infection in patients with clean-contaminated surgery, and some clean operations with the use of prophylactic antibiotics. The purpose of this study was to evaluate the use of prophylactic antibiotics in patients with laparotomy surgery in a hospital in Surabaya. The research method is descriptive operational with retrospective data. The results of this study obtained as many as 160 patients aged 46-55 years at 20.6%, the sex of the respondents were dominated by male sex 66.3%, and the diagnosis of generalized peritonitis was 46.9%. The use of prophylactic antibiotics is class I cephalosporin antibiotics (cefazolin) with a dose of 1000-2000 mg, which is by the 2011 Ministry of Health guidelines and IDSA (Infectious Diseases Society of America) 2013 . Copyright © 2022 Jsscr. All rights reserved. Keywords: Antibiotics;Prophylaxis; Laparotomy; Conformity Received: 2022-01-31 Accepted: 2022-02-10 Online: 2022-02-25