ORIGINAL ARTICLE PREDICTIVE VALUE OF SIMPLE BIOMARKERS OF MORTALITY IN PATIENTS WITH SEVERE HEART FAILURE IN EMERGENCY DEPARTMENT IN SUEZ CANAL UNIVERSITY HOSPITAL IN ISMAILIA Khaled Morsy Salama * , Monira T. Ismail * , Hanan M. Kamal ** and Basant S. Mousa * * Department of Emergency, Suez Canal University, Ismailia, Egypt., ** Department of Cardiology, Suez Canal University, Ismailia, Egypt. ABSTRACT Background:Heart failure (HF) has become one of the most significant problems in healthcare in the western world. There are over 26 million people who suffer from heart failure in the world. Half of all patients diagnosed with heart failure die within four years. It is critical to predicting if a patient will die soon so that an effective prevention can be employed. However, characteristics and outcome of HF patients are not well investigated in developing countries like Egypt. Methods: Was to assess the short-term predictive value of simple biomarkers (such as d-dimer, CRP& ESR) regarding cardiovascular mortality and major cardiovascular events in patients with severe heart failure. This is a cross-sectional study which included 141 patients. Results: According to ESR, CRP and d-dimer as predictors of hospital admission within one-month follow-up: 45.9% of the patients had moderately elevated ESR, 72.1% of the patients had high CRP and 13.1% of the patients had positive d-dimer. According to ESR, CRP, d-dimer as predictors of mortality within one month follow up: 83.3% of the patients had moderately elevated ESR within the first hour, 83.3% of the patients had high CRP, and 33.3% of the patients had positive d-dimer. Conclusion: ESR may be a good predictor of mortality within one month follow-up, while CRP, d-dimer are not. KEYWORDS: Heart failure mortality, ESR, CRP, d-dimer, Biomarkers. Introduction Heart failure (HF) has become one of the most important prob- lems in healthcare in the western world. The prevalence of heart Copyright © 2017 by the Bulgarian Association of Young Surgeons DOI:10.5455/ijsm.severe-heart-failure-predictive-biomarkers First Received: July 27, 2016 Accepted: September 03, 2016 Manuscript Associate Editor: George Baitchev (BG) Editor-in Chief: Ivan Inkov (BG) Reviewers: Mette Cathrine Orngreen (DK); Viorel Floreaa (US) 1 Khaled Moursy Salama, Lecturer of Emergency Medicine, Faculty of Medicine, Suez Canal University, Egypt. E-mail: khsalama@yahoo.com failure is about 2%-3% of the adult population, and it increases with age. There are over 26 million people who suffer from heart failure in the world, and there are over 3.5 million newly diagnosed people every year in Europe alone [1]. Half of all patients diagnosed with heart failure die within four years. It is fascinating to predict if a patient dies soon so that an effec- tive prevention can be employed. However, characteristics and outcome of HF patients are not well described in developing countries like Egypt. Documenting patients’ characteristics and the outcome might improve management of comorbidities asso- ciated with heart failure patients in Egypt as well as the disease outcome.[2] So, The aim of this study was to assess the short- term predictive value of simple biomarkers (such as d-dimer, CRP & ESR) regarding cardiovascular mortality and major car- diovascular events in patients with severe heart failure. Khaled Moursy Salama et al./ International Journal of Surgery and Medicine (2017) 3(1):37-41