Influence of Use of Insole on Blood Glucose Rate Diabetes Mellitus Type-2 Ignatius Heri Dwianto 1 Bambang Purwanto 2 and Sony Wibisono 3 1 Sports Health Sciences Faculty of Medicine, Airlangga University, Jl. Prof Moestopo 47. Surabaya, Indonesia 2 Department of Physiology Faculty of Medicine, Airlangga University, Surabaya, Indonesia 3 Department of Internal Medicine Dr. Soetomo Surabaya, Indonesia heri594@yahoo.co.id Keywords: Diabetes Mellitus, Eccentric Strain, Fasting Blood Glucose, Insole, Postprandial Blood Glucose. Abstract: Background: Tiptoeing is not easy to do continuously and, in the long term, tiptoe can be replaced by the use of insole. The use of insole at -10 ° angle for five days in healthy subjects has been proven to decrease fasting blood glucose levels and improve glucose tolerance in hyperglycemia patients. Objectives: This study is aimed prove the effect of insole use on the decrease of fasting blood glucose and postprandial blood glucose level after the use of insole in type 2 diabetes mellitus. Methods: Design of this study is pre and post-test with control and respondents of this study being people with diabetes mellitus type 2 divided into two groups in Paguyuban Diabetes and Hidup Sehat of “X” Hospital Surabaya. The treatment lasted for five days by providing shoes with insole-10° for one group while the other group’s shoes were not provided with any. Subjects’ blood from both groups was tested prior to treatment as well as post-treatment. Result: The result of data analysis of fasting blood glucose level in group with insole 0° using paired t-test shows p value 0.494 while the other group with insole 10° has p value 0.022. The blood glucose level two hours postprandial in the group with shoes with insole 0° has p value 0.082 and the group with shoes with insole 10° has p value 0.016. The use of shoes with insole -10⁰ for five days has an effect on decreasing fasting blood glucose and blood glucose level two hours postprandial. Conclusions: The results of this study were the use of insole -10⁰ decreased fasting blood glucose level and postprandial blood glucose level in type 2 diabetes mellitus and there was a difference of effect of insole -10 and flat insole (0⁰) on fasting blood glucose level and postprandial blood glucose level in type 2 diabetes mellitus. 1 INTRODUCTION One of the functions of the insole is used to provide comfort and protect the foot from trauma micro in diabetic condition and can be used to help improve the position of the foot and ankle and adjust the loading on the foot (Uccioli & Giacomozzi 2009). The results of the previous study stated that the use of insole with the angle of -10 ° for five days in healthy subjects decreased fasting blood glucose levels and improved glucose tolerance in patients with hyperglycaemia (Kusuma et al. 2016). By stimulating the expression of GLUT-1 it potentially helps to improve insulin sensitivity, which is impaired in type 2 diabetics (Rehman et al. 2012). To date, the effect of insole on blood glucose level of diabetes mellitus has not been proven. Diabetes mellitus is a major health problem. Current epidemiological studies have shown an increasing trend in incidence rates and the prevalence of type 2 diabetes mellitus in different parts of the world. The World Health Organization (WHO) predicts an increase in the number of people with Diabetes Mellitus (DM) in Indonesia from 8.4 million in 2000 to about 21.3 million in 2030 (Kpozehouen et al. 2015), while the International Diabetes Federation (IDF 2015) predicts an increase in the number of people with DM in Indonesia from 9.1 million in 2014 to 14 million in 2035. Several earlier studies have shown that eccentric strain can affect glucose uptake. In vitro trial, m. gastrocnemius can be stretched eccentrically up to 130% of the initial length, incorporated into glucose- diluted thyrode. The result is no muscle damage with a greater muscle contraction response and glucose uptake is also increased (Purwanto 2016). Eccentric strain due to the influence of insole use at -10 ° angle for five days in healthy subjects decreased Heri Dwianto, I., Purwanto, B. and Wibisono, S. Influence of Use of Insole on Blood Glucose Rate Diabetes Mellitus Type-2. In Proceedings of Surabaya International Physiology Seminar (SIPS 2017), pages 143-146 ISBN: 978-989-758-340-7 Copyright © 2018 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved 143