737 Copyright © 2017, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. Chapter 36 DOI: 10.4018/978-1-5225-1624-8.ch036 ABSTRACT In an attempt to foster inquiry-oriented learning in middle grades (grades 6 – 8), a technology medi- ated pedagogy integrating science and mathematics was promoted through Project SMILE (Science and Mathematics Integration for Literacy Enhancement). It involved in-service teachers in professional learning and classroom implementation over a period of two academic years, with the explicit goal of enhancing teachers’ ability to foster more authentic inquiry in their classes. This chapter describes the design of Project SMILE in the context of recent reform eforts in science and mathematics education, along with the theoretical underpinnings for the design. Project activities, followed by the research meth- odology employed to investigate the impact on both teachers and students are described next. Finally, research results and their implications are discussed with an eye toward the usefulness of integrating science and mathematics and involving specifc technological tools to foster greater inquiry-oriented learning in school science and mathematics. STEM Learning in Middle Grades by Technology- Mediated Integration of Science and Mathematics: Results of Project SMILE Pradeep Maxwell Dass Northern Arizona University, USA John T. Spagnolo Appalachian State University, USA