AIJR Preprints Section: Coronavirus Article Id: 90, Version: 1, 2020 URL:https://preprints.aijr.org/index.php/ap/preprint/view/90 {Click on above link to see the latest available version of this article} Version 1: Received: 23 May 2020 / Approved: 31 May 2020 / Online: 01 June 2020 Copyright © 2020. The Author(s). This is an open access preprint (not peer-reviewed) article under Creative Commons Attribution- NonCommercial 4.0 International license, which permits any non-commercial use, distribution, adaptation, and reproduction in any medium, as long as the original work is properly cited. However, caution and responsibility are required when reusing as the articles on preprint server are not peer-reviewed. Readers are advised to click on URL/doi link for the possible availability of an updated or peer-reviewed version. How to Cite: Sayed Ali Raza Shah et al. “Key Features of SARS-CoV-2 and Available Therapies for COVID-19”. AIJR Preprints, 90, version 1, 2020. https://preprints.aijr.org/index.php/ap/preprint/view/90 NOT PEER-REVIEWED Key Features of SARS-CoV-2 and Available Therapies for COVID-19 Sayed Ali Raza Shah 1 , * Abdullah 2 , S. Yousaf Shah 3 , Farhana Maqbool 4 , Atif Hameed 5 1 (M.Phil., Department of Microbiology, Hazara University Mansehra, KPK, Pakistan) 2 (M.Phil., Department of Microbiology, Abdul Wali Khan University, Mardan, KPK, Pakistan). 3 (MBBS, Medical officer at Ayub Teaching Hospital, Abbottabad, KPK, Pakistan). 4 (PhD, Department of Microbiology, Hazara University, Mansehra, KPK, Pakistan). 5 (MBBS, Medical officer at Ayub Teaching Hospital, Abbottabad, KPK, Pakistan). ABSTRACT The disease caused by severe acute respiratory syndrome (SARS-CoV2) is highly pathogenic and communicable infection, progressed in Wuhan city of China and then goes viral around the globe. The Genomic investigations exposed that Phylogenetically SARS-CoV2 resembles the other SARS-like bat viruses, therefore bats were also considered as the possible potential reservoir for SARS-CoV2. There are 2 prevalent types of SARS-CoV2, L type (~70%) and S type (~30%).The L strains are considered more infectious and virulent than the ancestral S strain. The positive sense single-stranded RNA genetic material contains 29891 nucleotides which codes for 9860 amino acids. The ORF1a/b is involved in carrying the translation of two (2) polyproteins, pp1a and pp1ab as well as the encoding of 16 NSPs (Non-structural proteins), and the leftover ORFS can bring about the encoding of non-essential and structural proteins. The origination source and transmission to humankinds is still not clear, but the intermediate hosts are supposed to have a significant role in the transfer and emergence of SARS-CoV2 from bats to humans. There is still no approved drug or vaccine available for Covid-19. In the current review, we condense and fairly evaluate the emergence and pathogenicity of SARS-CoV2, SARS-CoV and MERS-CoV. Moreover, we also discuss the treatment and vaccine developments strategies for Covid-19. Keywords: Coronaviruses; SARS-CoV2; Transmission; Infection; Outbreak; COVID-19 brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by AIJR Preprints