SKIN July 2021 Volume 5 Issue 4 Copyright 2021 The National Society for Cutaneous Medicine 399 RESEARCH LETTER Characterization of Clinical Outcomes in Patients with Cutis Marmorata Telangiectatica Congenita Nathan L. Bowers, MD, PhD 1 , Wasim Haidari, MD 1 , Jennifer J. Su, BS 1 , Jesus A. Cardenas-de la Garza, MD 1,2 , Steven R. Feldman, MD, PhD 1,3,4 , Joseph L. Jorizzo, MD 1 1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC 2 Department of Dermatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico 3 Departments of Pathology and Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC 4 Department of Dermatology, University of Southern Denmark, Odense, Denmark Cutis marmorata telangiectatica congenita (CMTC) is an uncommon, congenital, cutaneous vascular disease. The pathogenesis of CMTC remains unknown. Although considered as a benign condition, anomalies such as body asymmetry, vascular lesions, neurological and ophthalmic manifestations, hypoplasias/aplasias are frequently associated. However, whether these associations are due to reporting bias is a matter of debate. This study evaluated CMTC patients seen at our institution and examined their clinical outcomes. The Wake Forest Baptist Health institutional review board (Winston-Salem, North Carolina) approved this single-institution retrospective medical record review. Inclusion criteria included patients 18 years or younger diagnosed with CMTC from July 2009 – July 2019. Patients with CMTC were identified using ICD-19 code: 757.32 and ICD-10 codes: Q82.8 and R23.9. Patients with physiologic cutis marmorata were excluded. Primary outcome measures were presence of associated anomalies and improvement of skin over time. Demographics collected included age, sex, and race. Information on anatomic distribution of skin lesions was also extracted. Seventeen patients were identified using the inclusion criteria. All cases had parental reports of skin lesions present at or shortly ABSTRACT Cutis marmorata telangiectatica congenita (CMTC) is an uncommon, congenital, cutaneous vascular disease with an unknown pathogenesis. Although considered as a benign condition, anomalies such as body asymmetry are frequently associated. Herein we present a series of patients with diagnosis of CMTC with a focus on clinical outcomes. In our series, limb length abnormalities were the most common associate anomaly, occurring in 24% of the subjects, similar to other series with rates of 33% and 27% but higher than the general population (6.7%). Importantly, dermatologists should be aware of the frequently associated anomalies in CMTC, such as leg length discrepancy, which may have serious consequences if not recognize and treated.