www.chembiochem.org Accepted Article A Journal of Title: Natural Product Kuwanon-L Inhibits HIV-1 Replication Through Multiple-Target Binding Authors: Riccardo Martini, Francesca Esposito, Angela Corona, Roberto Ferrarese, Elisa Rita Ceresola, Laura Visconti, Cristina Tintori, Alessandro Barbieri, Andrea Calcaterra, Valentina Iovine, Filippo Canducci, Enzo Tramontano, and Maurizio Botta This manuscript has been accepted after peer review and appears as an Accepted Article online prior to editing, proofing, and formal publication of the final Version of Record (VoR). This work is currently citable by using the Digital Object Identifier (DOI) given below. The VoR will be published online in Early View as soon as possible and may be different to this Accepted Article as a result of editing. Readers should obtain the VoR from the journal website shown below when it is published to ensure accuracy of information. The authors are responsible for the content of this Accepted Article. To be cited as: ChemBioChem 10.1002/cbic.201600592 Link to VoR: http://dx.doi.org/10.1002/cbic.201600592