RESEARCH ARTICLE Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State Matthew P. Patricelli, Matthew R. Janes, Lian-Sheng Li, Rasmus Hansen, Ulf Peters, Linda V. Kessler, Yuching Chen, Jeff M. Kucharski, Jun Feng, Tess Ely, Jeffrey H. Chen, Sarah J. Firdaus, Anjali Babbar, Pingda Ren, and Yi Liu on June 22, 2017. © 2016 American Association for Cancer Research. cancerdiscovery.aacrjournals.org Downloaded from Published OnlineFirst January 6, 2016; DOI: 10.1158/2159-8290.CD-15-1105