www.rspsciencehub.com Volume 02 Issue 08 August 2020 International Research Journal on Advanced Science Hub (IRJASH) 291 A Review on the Relevance of Curcuminoids in Corona Pandemic Situation Lovely Jacob A 1 , Tom Cherian 2 1 Assistant Professor, Department of Chemistry, Little Flower College, Guruvayoor, Kerala, India 2 Dr.Tom Cherian, Assistant Professor, PG and Research Department of Chemistry, Christ College ,Irinjalakuda, Kerala, India lovely.a@littleflowercollege.edu.in 1 , drtomcherian@gmail.com 2 Abstract A hyperactive response by the immune system is said to be primarily responsible for pneumonia, also a fall out of a severe SARS-CoV-2 infection. Infection starts when the viral spike protein binds to its complementary host cell receptor. Viruses from the corona primarily attack epithelial cells. Depending on the species of the corona virus, they are transmitted from one host to another by either an aerosol, fomite, or faecal-oral route. Chloroquine and hydroxychloroquine are interferon blockers but they increase the risk of unsafe heart rhythm disturbances. Curcumin, a photochemical which occurs naturally in Curcuma longa, is known to have strong pharmacological properties.But it is essential to overcome the limitations for using it in medication. By docking, curcumin and its derivatives were shown to have the capacity to serve as spike protein inhibitors and thus viral entry.In this review, papers focused on structure, platforms and ill effects of Corona virus, and also discloses the nutrients which include mainly poly phenols and antioxidants containing curcuminoids which has antivirus and anti inflammatory properties; the nutrients under discussion can support the healthy functioning and strengthening of the respiratory system. Key words: Corona pandemic, Curcuminoids, Antioxidants, Antivirus, Anti inflammatory, Molecular docking 1. Introduction Owing to its high mortality, corona virus infection has gained significant attention in the last two decades. An unknown respiratory infection emerged from Wuhan, China has reported in late 2019. The source of this infection has been described as a novel corona virus associated with Extreme Acute Respiratory Syndrome ( SARS), which triggered 2002-2004 outbreaks and 2012 Middle East Respiratory Syndrome (MERS). By early March 2020, the new SARS-CoV-2 corona virus had infected more than 90,000 people worldwide and killed at least 3,100 people [1]. COVID-19 's key clinical sign is the development of respiratory symptoms but certain patients experience significant complications of the cardiovascular and the renal. The mechanism by which this virus induces problems to establish treatment options is urgently to be understood. According to the WHO, the most common diagnosis for severe COVID-19 is severe pneumonia [2]. A hyperactive response by the immune system is said to be primarily responsible for pneumonia, also a fall out of a severe SARS- CoV-2 infection. In this present scenario, we focused on papers which revealed the structure, platforms and ill effects of corona virus on human body. It has led us to look for different treatments in this field and find that there is no known successful pharmaceutical treatment as of this time, although it is much needed [3]. In multicenter clinical trials performed in China, chloroquine and hydroxy