This article is protected by copyright. All rights reserved RESEARCH ARTICLE Morin-dependent inhibition of low molecular weight protein tyrosine phosphatase (LMW- PTP) restores sensitivity to apoptosis during colon carcinogenesis: studies in vitro and in vivo, in an Apc-driven model of colon cancer. † Running title: LMW-PTP inhibition enhances sensitivity to 5-FU in Pirc rats mutated in Apc Giulia Lori 1 , Paolo Paoli 1§ , Angelo Pietro Femia 2 , Erica Pranzini 1 , Anna Caselli 1 , Katia Tortora 2 , Andrea Romagnoli 2 , Giovanni Raugei 1 , Giovanna Caderni 2 Authors’ affiliations: 1 Department of Experimental and Clinical Biomedical Sciences“Mario Serio”, University of Florence, 50 Viale Morgagni, 50134 Florence, Italy. 2 NEUROFARBA Department, Section of Pharmacology and Toxicology, University of Florence, 6 Viale Pieraccini, 50139 Florence, Italy. § Corresponding author: Dr. Paolo Paoli, PhD, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy, tel-39-055- 2751248, e-mail: paolo.paoli@unifi.it E-mail address of authors Giulia Lori: Giulia.lori87@gmail.com Paolo Paoli: Paolo.paoli@unifi.it Angelo Pietro Femia: Pietro.femia@unifi.it Erica Pranzini: Erica.pranzini@gmail.com Anna Caselli: Anna.caselli@unifi.it Katia Tortora: Katia.tortora@unifi.it Andrea Romagnoli: Andrea.romagnoli@unifi.it Giovanni Raugei: Giovanni.raugei@unifi.it Giovanna Caderni: Giovanna.caderni@unifi.it † This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/mc.22962] Additional Supporting Information may be found in the online version of this article. Received 30 May 2018; Revised 22 November 2018; Accepted 6 December 2018 Molecular Carcinogenesis This article is protected by copyright. All rights reserved DOI 10.1002/mc.22962