Archives of Dental Research 2021;11(2):108–111 Content available at: https://www.ipinnovative.com/open-access-journals Archives of Dental Research Journal homepage: https://www.adr.org.in/ Review Article Diagnostic utility of saliva and its implication in detection of Covid-19 and other diseases Shivlal M Rawlani 1 , Rakhi M Chandak 2, *, Pranali S Thakare 2 , Ramhari S Sathawane 2 , Ashish B Lanjekar 2 , Romita D Gaikwad 2 , Dhiran A Talatule 2 , Runal P Bansod 2 1 Dept. of Oral Medicine & Radiology, V.Y.W.S. Dental College, Amravati, Maharashtra, India 2 Dept. of Oral Medicine & Radiology, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital, Nagpur, Maharashtra, India ARTICLE INFO Article history: Received 21-07-2021 Accepted 19-08-2021 Available online 31-12-2021 Keywords: Salivary diagnostics safe Noninvasive Cost effective Novel corona virus ABSTRACT Saliva is a valuable tool for early detection, better treatment, and a better prognosis. Early detection of illnesses is sometimes challenging, and it necessitates additional clinical and laboratory tests, which can delay treatment and have a significant impact on prognosis. A large range of chemicals may be found in saliva, providing useful information for clinical diagnostic purposes. The coronavirus disease pandemic (Covid-19) is the world’s largest challenge and global health disaster since World War II. Controlling the epidemic in the community and in hospitals requires a quick and precise diagnosis of Covid-19. For Covid-19 diagnostic testing, nasopharyngeal and oropharyngeal swabs are the suggested specimen types. The collection of these specimens necessitates intimate contact between healthcare staff and patients, which increases the risk of viral transmission. As a result, nasopharyngeal or oropharyngeal swabs are not recommended for sequential viral load monitoring. Saliva specimens are simply collected by having the patient spit into a sterile container. Saliva collection is non-invasive and significantly reduces healthcare personnel’ exposure to Covid-19. To develop quick chair side assays for the detection of Covid-19, more study is needed to investigate the potential diagnostic of Covid-19 in saliva. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: reprint@ipinnovative.com 1. Introduction Body fluids give a broad view on the health of many organs and biological processes. The human body is made up of a range of fluids, including urine, blood, and saliva, all of which include an elevated number of proteins that have been linked to a number of systemic and oral illnesses. These fluids have found extensive clinical applications in the diagnosis and monitoring of human health. Saliva is a valuable tool for early detection, better treatment, and a better prognosis. Early detection of illnesses is sometimes * Corresponding author. E-mail address: rakhi.chandak@sdk-dentalcollege.edu.in (R. M Chandak). challenging, and it necessitates additional clinical and laboratory tests, which can delay treatment and have a significant impact on prognosis. 1 Saliva is a liquid released by salivary glands that aids in swallowing, inhibits the growth of harmful germs, and keeps the oral mucosa healthy by keeping it from drying out and lubricating hard food boluses. Parasympathetic and sympathetic stimulation govern salivary secretions, resulting in thick and thin saliva, respectively. These salivary contents are systemic illness indicators, and some of them have been considered as local disease markers. 2 https://doi.org/10.18231/j.adr.2021.018 2277-3401/© 2021 Innovative Publication, All rights reserved. 108