International Journal of Basic and Applied Chemical Sciences ISSN: 2277-2073 (Online) An Open Access, Online International Journal Available at http://www.cibtech.org/jcs.htm 2015 Vol. 5 (1) January-March, pp.79-88/Kumar et al. Research Article © Copyright 2014 | Centre for Info Bio Technology (CIBTech) 79 NEW INSIGHTS TO THE CHEMISTRY OF BENZOTHIAZEPINES-AN OVERVIEW *Ajay Kumar K. 1 , Renuka N. 1 , Raghavendra K.R. 2 , Vasanth Kumar G. 1 and Ranjitha B.K. 1 1 Department of Chemistry, Yuvaraja College, University of Mysore, Mysore, India 2 Department of Chemistry, Manasa Gangothri, University of Mysore, Mysore, India *Author for Correspondence ABSTRACT The compounds containing the benzothiazepine moiety are important targets in synthetic and medicinal chemistry. Benzothiazepines are widely found as the core structure in a large number of compounds that possess important pharmaceutical activities. These have been the recent target of numerous methodologies due to their prevalence as scaffolds in synthesis of bioactive compounds. The main objective of this review is to provide an up to date information about the synthetic methodologies developed, chemical transformation to bioactive molecules and pharmacological application associated with benzothiazepines with a more emphasis on 1,4-benzothiazepines and 1,5-benzothiazepines. Keywords: Benzothiazepines, Cyclocondensation, Microwave, Antimicrobial, Antioxidant, Anti- inflammatory INTRODUCTION Thiazepines are the important members of seven membered heterocyclic compounds that contain nitrogen and sulfur atoms in a ring system. Depends upon the position of the nitrogen and sulfur atoms in a ring, these were categorized in to 1,3-thiazepine (1a) and 1,4-thiazepine (1b). The partially reduced forms of thiazepines are named as dihydrothiazepines (2a-b) and tetrahydrothiazepines (3a-b); while completely reduced forms are thiazapanes (4a-b). Benzothiazepines are the fused heterocycles in which the thiazepine ring is fused to an aromatic ring. Depends upon the position of the nitrogen and sulfur atoms in a seven membered ring that fused to the benzene ring; Benzothiazepines are categorized in to 1,3-benzothiazepine (5a) and 1,4-benzothiazepine (5b) and 1,5-benzothiazepine (5c).