Copyright@ Abdelkareem A Ahmed | Biomed J Sci & Tech Res | BJSTR. MS.ID.005050. 23917 Research Article ISSN: 2574 -1241 Gum Arabic Modifies Glucocorticoid Metabolic Enzymes Gene Associated with Decreased Plasma Corticosterone Levels in Mice Abdelkareem A Ahmed 1-4 *, Mohammed Elmujtba Adam Essa 4 , Adriano Mollicad 5 , Azzurra Stefanucci 4,5 , Gokhan Zengin 4,6 , Hussain Ahmed 7 and Ayman Sati Sati Mohamed 4 1 Department of Physiology and Biochemistry, Faculty of Veterinary Science, University of Nyala, Sudan 2 Institute of Molecular Biology, University of Nyala, Sudan 3 Biomedical Research Institute, Darfur University College, Sudan 4 Department of Clinical Medicine, Medical and cancer Research Institute, Sudan 5 Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, Italy 6 Department of Biology, Science Faculty, Selcuk University, Konya, Turkey 7 College of Veterinary and Animal Science, the Islamia University, Bahawalpur, Pakistan *Corresponding author: Abdelkareem A Ahmed, Department of Physiology and Biochemistry, Faculty of Veterinary Science, University of Nyala, Nyala, 583, Sudan DOI: 10.26717/BJSTR.2020.31.005050 Introduction Glucocorticoids (GCs), corticosterone in rodents and cortisol in humans are endogenous stress hormones that exert key physiological functions [1] on various tissues [2] including liver [3] and skeletal muscle [4]. GCs affect almost all organs and ARTICLE INFO ABSTRACT Glucocorticoids (GCs) are a class of stress hormones that play a large number of biological actions in the body. The levels of GCs regulated by the intracellular enzyme 11β-hydroxysteroid dehydrogenases (11β-HSD 1 & 2) and are associated with the pathogenesis of metabolic syndrome. Here we aimed to investigate effect of Gum Arabic (GA) on GCs plasma corticosterone concentrations and its metabolic enzymes gene expression in mice. In the present study, 40 female CD-1 mice of 90 days old were randomly divided into two groups (20 of each group). Control group and GA group offered GA in the form of drink (10% w/v) for 15 weeks. GA in drinking water significantly (P<0.05) decreased food intake, body weight associated with reduction of visceral adipose tissue. GA supplementation significantly (P<0.01) decreased blood glucose, total cholesterol, and very low-density lipoprotein (VLDL) whereas increased high-density lipoprotein (HDL) concentrations compared to the control. However, supplementation of GA did not change triglycerides or very LDL. Interestingly, GA significantly (P<0.05) decreased plasma corticosterone associated with downregulation of hepatic 11β-HSD1 and glucocorticoid receptor (GR) mRNA expression compared to the control. Conversely, the treatment of GA increased hepatic 11β-HSD2 mRNA expression. In addition, the treatment of GA significantly (P<0.05) decreased muscular 11β-HSD1 compared to the control. No changes were observed in muscular GR and mineralocorticoid receptor. In conclusion, GA may enhance metabolic disorders through modification of hepatic 11β-HSDs mRNA expression which may ameliorate metabolic disorder complications. Further studies required to elucidate the molecular mechanisms of GA on GCs. Received: September 29, 2020 Published: October 12, 2020 Citation: Abdelkareem A Ahmed, Mohammed Elmujtb Adam Essa, Adriano Mollicad, Azzurra Stefanucci, Gokhan Zengin, et al. Gum Arabic Modifies Glucocorticoid Metabolic Enzymes Gene Associated with Decreased Plasma Corticosterone Levels in Mice. Biomed J Sci & Tech Res 31(1)-2020. BJSTR. MS.ID.005050. Keywords: Gum Arabic; Glucocorticoids Receptors Mice; Mineralocorticoid Receptor; 11β-Hydroxysteroid Dehydrogenases; Corticosterone