Submit Manuscript | http://medcraveonline.com Abbreviations: EBRT; external beam radiotherapy Introduction Hidradenoma was frst recognized as a distinct entity by Mayer in 1941. 1 Its malignant form, the malignant nodular hidradenoma is a very rare adnexal tumor. Its incidence is as low as <0.001%. 2 It has been reported most frequently on the head and neck and rarely on the extremities. The natural history of the disease is varied. However, owing to the propensity to metastasize to regional lymph nodes and distant viscera the tumor is said to be aggressive. 3 There is no clear consensus on its treatment till date. Surgical excision is the preferred choice of treatment wherever possible. The role of adjuvant therapy is controversial. 4 We report the rare case of Malignant Nodular Hidradenoma Nose in an 80 year old male who responded miraculously to Radiotherapy. Case Presentation An 80-years old male non-smoker presented to radiotherapy department with swelling on dorsum of nose for the past 1 year which was insidious in onset, gradually progressive, associated with foul smelling pus discharge and mild pain. There is no history of loss of weight and loss of appetite. Patient had no history of comorbidities. No signifcant family history was reported. General physical and systemic examination was normal. Local examination revealed an ulceroproliferative growth of size 5×5cm over dorsum of nose extending to involve the left eye with foul smelling pus discharge from it (Figure 1). Histopathology and immunohistochemical profle confrmed the diagnosis as malignant nodular hidradenoma of nose. Magnetic resonant imaging of face and Neck revealed a soft tissue lesion involving skin and subcutaneous tissue of nose, extending to left periorbital region with infltration into left preseptal space, with loss of fat planes with left medial rectus muscle and anterior sclera and reduced space of anterior chamber along with infltration of left nasal wall with extension into nasal cavity. There were no metastases as evident from chest X-ray and ultrasonography abdomen. Oncosurgery opinion was sought for consideration of radical surgery. However due to the massive extent of the disease, it was deemed inoperable. Thus, patient was initially treated with palliative intent using a hypofractionated External beam Radiotherapy (EBRT) regimen of 20 Gy/5 fractions/ 1week (4 Gy per fraction). Patient tolerated the treatment well (Figure 2) (Figure 3). Upon evaluation of response to treatment one month after completion of EBRT patient was found to have very good subjective as well as objective response as evident in Figure 4. Patient is asymptomatic and was planned for supplementary Radiotherapy; however he lost to follow-up subsequently. Figure 1 Clinical photograph of patient at presentation showing an ulceroproliferative growth of size 5×5 cm over dorsum of nose extending to involve the left eye. J Cancer Prev Curr Res. 2018;9(3):97‒99. 97 © 2018 Nongkynrih et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially. Miraculous response to radiotherapy in a rare case of malignant nodular hidradenoma nose Volume 9 Issue 3 - 2018 Anthialisha Nongkynrih, Karun Kamboj, Anil Kumar Dhull,Vivek Kaushal Department of Department of Radiation Oncology, Post Graduate Institute of Medical Sciences, India Correspondence: Anil Kumar Dhull, Radiation Oncologist, Department of Radiation Oncology, Post Graduate Institute of Medical Sciences, PO Box 100, GPO Rohtak-124001, Haryana, India, Fax +91-126-22-99999; Email anilkdhull@gmail.com Received: February 01, 2018 | Published: May 08, 2018 Abstract Malignant nodular hidradenoma is very rare adnexal tumor with exceedingly low incidence of 0.001%. The biological behavior of the tumor is aggressive, with local recurrences reported in more than 50% of the surgically-treated cases. Treatment options are surgery and/or Radiotherapy. Till date there is no clear consensus on its treatment. We report a rare case of malignant nodular hidradenoma nose in an 80-years old male who responded miraculously to Radiotherapy. Keywords: malignant hidradenoma, radiotherapy, sweat gland tumor Journal of Cancer Prevention & Current Research Case Report Open Access