1044 https://oamjms.eu/index.php/mjms/index Scientifc Foundation SPIROSKI, Skopje, Republic of Macedonia Open Access Macedonian Journal of Medical Sciences. 2021 Oct 01; 9(B):1044-1047. https://doi.org/10.3889/oamjms.2021.7075 eISSN: 1857-9655 Category: B - Clinical Sciences Section: Endocrinology Concordance between Triglyceride Glucose Index and Admission Insulin Resistance Index in Non-diabetic Subjects of Acute Coronary Syndrome Andi Irham 1 , Husaini Umar 2 *, Fabiola Maureen Shinta Adam 2 , Idar Mappangara 3 , Syakib Bakri 4 , Risna Halim 5 , Alfan Zainuddin 6 1 Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; 2 Department of Internal Medicine, Division of Endocrine Metabolic and Diabetes, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; 3 Department of Internal Medicine, Division of Cardiology and Vascular Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; 4 Department of Internal Medicine, Division of Nephrology and Hypertension, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; 5 Department of Internal Medicine, Division of Tropical Medicine and Infectious Disease, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; 6 Department of Biostatistics, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia Abstract BACKGROUND: Acute coronary syndrome (ACS) is the leading cause of death in the world and is closely related to insulin resistance (IR). The examination of the triglyceride glucose (TyG) Index and admission IR index (AIRI) can be an alternative examination to assess IR. AIM: The aim of the study was to analyze the concordance between the TyG index and AIRI in assessing IR in nondiabetic subjects of ACS. METHODS: This study was a cross-sectional study using secondary data from ACS patient medical records in Wahidin Sudirohusodo Hospital Makassar from September 2020 until April 2021. An examination of RBG, TyG, and fasting insulin was performed. The statistical test results were considered signifcant if the p < 0.05. RESULTS: This study included 67 subjects, of which 54 were male and 13 were female, there were 24 people aged <50 years, 43 people aged 50 years old, with a mean of 55.15 ± 12.71 years, a diagnosis of ST-elevation myocardial infarction (STEMI) 25 people, non STEMI 34 people and unstable angina pectoris 8 people, p < 0.05. The receiver operating characteristic curve showed that the cut-of value of the TyG index in predicting AIRI was 3141, with a sensitivity of 88.98% and specifcity of 59.09%. The OR value revealed that subjects with a TyG index of >9.06 indicated an 11-time greater risk for IR than subjects with a TyG index ≤9.06. CONCLUSIONS: There was a signifcant concordance between the TyG index and the AIRI in non-diabetic acute coronary syndrome patient. Edited by: Ksenija Bogoeva-Kostovska Citation: Irham A, Umar H, Adam FMS, Mappangara I, Bakri S, Halim R, Zainuddin A. Concordance between Triglyceride Glucose Index and Admission Insulin Resistance Index in Non-diabetic Subjects of Acute Coronary Syndrome. OpenAccess Maced J Med Sci. 2021 Oct 01; 9(B):1044-1047. https://doi.org/10.3889/oamjms.2021.7075 Keywords: Insulin resistance; Triglyceride glucose index; Admission insulin resistance index; Non-diabetic of acute coronary syndrome *Correspondence: Husaini Umar, Division of Endocrine Metabolic and Diabetes, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. E-mail: husaini_umar65@yahoo.co.id Received: 16-Aug-2021 Revised: 04-Sep-2021 Accepted: 21-Sep-2021 Copyright: © 2021 Andi Irham, Husaini Umar, Fabiola Maureen Shinta Adam, Idar Mappangara, Syakib Bakri, Risna Halim, Alfan Zainuddin Funding: This research did not receive any fnancial support Competing Interests: The authors declare that they have no competing interests. Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution- NonCommercial 4.0 International License (CC BY-NC 4.0) Introduction Cardiovascular disease is the leading cause of death in the world and is often associated with various comorbidities such as obesity, abnormal lipid profle, and insulin resistance (IR) [1], [2]. The most common cardiovascular disease is acute coronary syndrome (ACS). ACS is divided into three groups, namely, ST-elevation myocardial infarction (STEMI), non STEMI (NSTEMI), and unstable angina (UA) [3]. The high population with chronic disease associated with IR has been widely reported worldwide [4]. The mechanism of IR in the heart is complex and multifactorial. Impaired insulin-stimulated glucose absorption is still a common problem, changes in signaling kinases can be increased or decreased, thus impacting cardiac structure and function. IR generally occurs mainly as a result of obesity, excess calories, lack of physical activity, genetics, and age. IR is associated with many serious medical conditions such as type 2 diabetes mellitus, hypertension, atherosclerosis, and metabolic syndrome (MetS) [5]. Systemic infammation also contributes to IR, proinfammatory cytokines induce IR which can afect glucose and fatty acid utilization by inducing IR, infammation increases the heart’s dependence on triglycerides from the liver and free fatty acids from adipose tissue for energy [6]. Obesity can increase circulating concentrations of infammatory cytokines, such as interleukin-6 tumor necrosis factor-α and leptin [2]. Hyperinsulinemia Euglycemic Clamp is still the gold standard to diagnose IR, but this method is expensive, invasive, and difcult to perform in health