Acknowledgments The authors are indebted to Dr Achyut Aryal, who has done in-depth study of brown bears in Nepal, for the critical appraisal of this review. Dr Alok Atreya wishes to acknowl- edge Annapurna Conservation Area Project, Lomanthang, Upper Mustang, for the courtesy of Figure 1, which is a specimen of brown bear claw recovered from the region in 2010. The corresponding author of this review, Dr. Tanuj Kanchan and the other authors wish to acknowledge their respective institutions for promoting research and publications in journals of repute and standing. Alok Atreya, MD Department of Forensic Medicine, Manipal Teaching Hospital, Pokhara, Nepal Tanuj Kanchan, MD Department of Forensic Medicine, Kasturba Medical College, Manipal University, Mangalore, India Samata Nepal, MBBS Department of Community Medicine, Manipal Teaching Hospital, Pokhara, Nepal Jenash Acharya, MD Department of Forensic Medicine, Kathmandu Medical College, Kathmandu, Nepal References 1. Aryal A. Brown bear conservation action plan in Nepal: efforts, challenges and achievements. World J Zool. 2012;7:75–78. 2. Silwal T, Shrestha BP, Bhatta BP, Devkota BP. Revenue distribution pattern and parkpeople conflict in Chitwan National Park, Nepal. BankoJanakari. 2013;23:35–41. 3. Rasool A, Wani AH, Darzi MA, et al. Incidence and pattern of bear maul injuries in Kashmir. Injury. 2010; 41:116–119. 4. Brown G. Bear anatomy and physiology In: The Great Bear Almanac. New York: Lyons & Burford; 1993. In Response to Ultraendurance Athletes With Type 1 Diabetes: Leadville 100 Experience, by Khodaee et al To the Editor: The letter by Khodaee et al 1 nicely describes the performance of 19 athletes with type 1 diabetes (DM1) out of 7215 total athletes competing in the 2011–2013 Leadville 100, a 161-km mountain bike race and 161-km ultramarathon run. There was no statistical difference between the 68.4% completion rate of the DM1 athletes and the other endurance athletes. However, concern was expressed in this letter about awareness of, or adherence to, diabetes management guidelines. Education for DM1 patients on multiple daily injec- tions or pumps usually (or should) include exercise instructions for reduced insulin basal needs, carbohydrate boluses, and correction boluses as well as increased use of glucose monitoring, target ranges of glucose to avoid hypoglycemia, and calorie intake. All of this is labor- intensive. Insulin adjustments are highly individualized and involve some trial and error, but are helped especially by the ever-increasing sophistication of insulin pumps, pump trainer/educators, and pump users. Guidelines by the American Diabetes Association 2 are expectedly generalized. More specifics are available, for example, from other sources about endurance athletes with DM1. 3 In the arduous Leadville 100, perhaps the patient-provider (s) relationship, the Internet, social media, and personal experience offered detailed advice for individual insulin management. Or perhaps information was available from Team Novo Nordisk, a global all-diabetes sports team of cyclists, triathletes, and runners, spearheaded by the world’ s first all-diabetes professional cycling team and sponsored by the Danish insulin manufacturer Novo Nordisk. 4 I agree with the authors that further studies are needed, but they are hard to come by in such a setting. Until that day arrives, are there any practical tips that can be gleaned from their review? For example, was there any prerace diabetes planning vs actual implementation to change doses of insulin before, during, and after the event when hypoglycemia can still strike? As most were probably pump users, were pump basal infusions reduced and by how much, or temporarily suspended? Were carb boluses cut, say, in half? Were square-wave profiles used rather than simple boluses? Were insertion site set failures common? Were continuous glucose-monitoring systems that measure interstitial glucose levels accurate or useful in this dynamic setting? This was a retrospective study with limitations, and such information may not be available from the entire group, but even individual or anecdotal information would be helpful for both provi- ders and athletes with DM1. Thank you. Harvey V. Lankford, MD Richmond, VA References 1. Khodaee M, Riederer M, VanBaak K, Hill JC. Ultraendur- ance athletes with type 1 diabetes: Leadville 100 experi- ence. Wilderness Environ Med. 2015;26:273–275. Letters to the Editor 588