Science Innovation 2016; 4(5): 235-241 http://www.sciencepublishinggroup.com/j/si doi: 10.11648/j.si.20160405.13 ISSN: 2328-7861 (Print); ISSN: 2328-787X (Online) Complex Behaviour of Bile Salts at Various Temperatures Under the Influence of Antidepressant Drug (Imipramine) in Aqueous Solution Shweta Singh 1 , Santosh K. Sar 1, * , Tonmoy Ray 2 1 Department of Applied Chemistry, Bhilai Institute of Technology, Durg, (C. G.) India 2 Department of Biotechnology, National Institute of Technology, Durgapur, (W. B.) India Email address: Santoshsar@hotmail.com (S. K. Sar) * Corresponding author To cite this article: Shweta Singh, Santosh K. Sar, Tonmoy Ray. Complex Behaviour of Bile Salts at Various Temperatures Under the Influence of Antidepressant Drug (Imipramine) in Aqueous Solution. Science Innovation. Vol.4, No.5, 2016, pp.235-241. doi: 10.11648/j.si.20160405.13 Received: September 23, 2016; Accepted: October 6, 2016; Published: November 7, 2016 Abstract: The present method was based on the effect of bile salt (Sodium cholate and Sodium deoxy cholate) on the dissolution of Antidepressant drug like Imipramine. Sodium cholate and Sodium deoxycholate is a type of anionic surfactants form mixed micelle with Imipramine and influence its rate of dissolution. The micellization behavior of binary anionic bile salt surfactant mixtures was investigated by conductivity method and various thermodynamical parameters are calculated. The results of the study have been analyzed by using Clint’s, Rubingh’s, and Motomura’s theories for mixed binary systems. Keywords: Antideprassant Drug, Sodium Cholate, Sodium Deoxycholate, Conductometer, Critical Micelle Concentration, Counter Ion Dissociation 1. Introduction Surfactants word is made up of three different word “surface active agent”. It has two different part -water-loving or hydrophilic and water-hating or hydrophobic. Due to presence of its unique structure it is also known as amphiphilic or amphipathic molecules and due to its nature hydrophilic group of Surfactants forms hydrogen bonds with water molecules, while due to hydrophobic nature hydrocarbon chains aggregate and moving away from the water molecules. Due to these properties surfactants is soluble in water. In aqueous solutions, they form organized bunch like structures called micelles. Surfactants are further classifies in to various part according to functional group present in it is-Anionic, Cationic, Zwitter ionic, Nonionic and Gemini surfactants. Surfactants play important role in almost every sector of industry like oil recover, pharmaceutical, physical and organic chemistry, cosmetic industry, food science etc. Micelles have importance property in various industries but basically it play important role in pharmaceutical industry because it have ability to dissurf solve sparingly soluble active substance like drug in aqueous solution. Important role of micelle is in delivery of drug towards targeted area and increase its bioavaibility. It also attempt to minimize drug degradation, its loss and to prevent its harmful side effects (16). Micelles as drug carriers present some advantages when compared to other alternatives such as soluble polymers and liposomes. Micellar systems can solubilize poorly soluble drugs and thus increase their bioavailability, they can stay in the body (blood) long enough to provide gradual accumulation in the required area, and their sizes permit them to accumulate in areas with leaky vasculature (9). In general, surfactants play an important role basically in pharmaceutical biotechnology fields, since they are largely utilized in various drug dosage forms to control wetting, stability, bioavailability, among other properties (1). It is important to notice that lyophobic colloids, such as polymers, require certain energy to be applied for their formation, are quite unstable from the thermodynamic point of view, and frequently form large aggregates. Association colloids such as micelles, on the other hand, can form spontaneously under certain conditions (self- assembling systems), and are