This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jfb.14317. 21 Feb 2020 The dietary anthocyanin delphinidin prevents bone resorption by inhibiting Rankl- induced differentiation of osteoclasts in a medaka (Oryzias latipes) model of osteoporosis Nurgul Imangali 1 , Tien Quang Phan 1 , Gail Mahady 2 , Christoph Winkler 1,# 1 Department of Biological Sciences (DBS) and Centre for Bioimaging Sciences (CBIS), National University of Singapore, Singapore, 117543 Singapore, 117557 2 Department of Pharmacy Practice, College of Pharmacy, PAHO/WHO Collaborating Centre for Traditional Medicine, University of Illinois, Chicago, USA KEY WORDS: Osteoporosis, bone remodelling, homeostasis, osteoblast-osteoclast coupling, medaka, anthocyanin, delphinidin. # Corresponding author: Christoph Winkler Phone: +65-6516 7376 Fax: +65-6779 2486 dbswcw@nus.edu.sg This article is protected by copyright. All rights reserved.