BIOSCIENCES BIOTECHNOLOGY RESEARCH ASIA, August 2014. Vol. 11(2), 863-868 * To whom all correspondence should be addressed. Tel.: +989123715287; E-mail : sami.fartook@yahoo.com Quantitative Assessment of MRI Features in Patients with Relapsing-Remitting Multiple Sclerosis Babak Shekarchi 1 , Samaneh Fartook Zadeh 2 *, Azim Mehvar 3 and Mohamad Sabahi 4 1 Department of Radiology AJA University of Medical Sciences, Tehran Iran. 2 Department of Cardiology AJA University of Medical Sciences, Tehran Iran. 3 Department of Pediatric AJA University of Medical Sciences, Tehran Iran. 4 Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, University of Tehran Iran. doi: http://dx.doi.org/10.13005/bbra/1349 (Received: 10 May 2014; accepted: 20 June 2014) Relapsing-remitting multiple sclerosis (RRMS) is a chronic inflammatory demyelinating disease of the central nervous system. Magnetic Resonance Imaging (MRI) has a remarkable role in the assessment of the disease. The aim of the study is to evaluate MRI features and also to determine linear correlation between them. Nineteen RRMS patients (5 males, 14 females) have been included in this study. Neurological examination using EDSS scores was performed for all patients. Each patient underwent T1, T2, Flair and DWI imaging. Twenty different features were evaluated in the research. Four features obtained directly from images, contain: DWI lesion size, number of DWI lesion, T2 lesion size and number of T2 lesion. In addition, EDSS is considered as one of the features. The volume of the lesion is presented as feature of lesion volume which is obtained by suitable software. In this paper we proposed a new method to calculate the rest of MRI features. The method uses histogram analysis of mean parenchymal diffusivity (MPD) map to calculate some features. The obtained features from the method contain: moment 2 to moment 6 (m2-m6), kurtosis, skewness, peak position (PP), peak height (PH), entropy (ENT), MPD-value, white matter fraction (WMF), gray matter fraction (GMF) and brain parenchymal fraction (BPF). Statistical results show EDSS has significant linear correlation with DWI lesion size, number of DWI lesion size, T2 lesion size and PP (P<0.05, R=[0.5-0.6]). All moments, m2- m6, kurtosis, skewness and PH have significant linear correlation together (P<0.05, R=[0.8- 1]). According to the results, ENT has negative significant correlation with m2-m6, kurtosis, skewness, PH (P<0.05, R=[-0.8-(-0.6)]) but has positive significant correlation with MPD-value and BPF (P<0.05, R=0.5). MPD-value has negative linear correlation with m2-m6, lesion volume and PH (P<0.05, R=[-0.8-(-0.5)]). The proposed method and features could be helpful in the analysis of treatment planning protocol and will be beneficial in the study of treatment effects. Key words: Histogram analysis, MRI features, DWI, RRMS, MS lesion. One of the most common progressive diseases of central nervous system (CNS) is multiple sclerosis (MS) which is a chronic inflammatory demyelinating disease 1,2 . Myelin sheath is the fast transmission responsible of signals between neurons. Because of the damage of the myelin, MS changes the structure and morphology of the brain. Loss of myelin or demyelination will disrupt the signal transmission of the nervous system. The demyelination causes malfunction of body, such as sever muscle weakness, blurred vision and cognitive difficulties 3 . MS patients are classified in four clinical types 4,5 : relapsing- remitting MS (RRMS), secondary-progressive MS (SPMS), primary-progressive MS (PPMS), relapsing-progressive (RPMS). Each type of MS affects the patients in unique ways. For quantifying