Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia Adegboyega Sapara, Dominic H Ffytche, Michael A Cooke, Steven CR Williams, Veena Kumari Adegboyega Sapara, Michael A Cooke, Veena Kumari, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom Dominic H Ffytche, Department of Old Age Psychiatry and Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom Steven CR Williams, Department of Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, United Kingdom Veena Kumari, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London SE5 8AF, United Kingdom Author contributions: Sapara A, Ffytche DH and Kumari V designed the study; Cooke MA carried out the neuropsychological assessments; Williams SCR assisted with neuroimaging data acquisition; Sapara A performed all analyses and wrote the manuscript under Ffytche DH and Kumari V’s joint supervision. Supported by The Wellcome Trust, United Kingdom and was carried out as part of the frst author’s PhD research under Professor Veena Kumari and Dr Dominic ffytche’s supervision, Nos. 067427 and 072298; Professor Kumari is part funded by the Biomedical Research Centre for Mental Health at the Institute of Psychiatry, Psychology and Neuroscience King’s College London, and the South London and Maudsley NHS Foundation Trust, United Kingdom (to Kumari V). Institutional review board statement: The study procedures had the approval (reference number 209/02) of the ethics committee of the Institute of Psychiatry and South London and Maudsley Foundation NHS Trust, London. Informed consent statement: All participants provided written informed consent. Confict-of-interest statement: None of the authors declare any confict of interest in this study. Data sharing statement: The anonymised dataset is available from the frst author and the corresponding author. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/ Manuscript source: Invited manuscript Correspondence to: Veena Kumari, PhD, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London SE5 8AF, United Kingdom. veena.kumari@kcl.ac.uk Telephone: +44-207-8480233 Received: March 2, 2016 Peer-review started: March 2, 2016 First decision: April 15, 2016 Revised: June 23, 2016 Accepted: July 11, 2016 Article in press: July 13, 2016 Published online: September 22, 2016 Abstract AIM To define regional grey-matter abnormalities in schizo- phrenia patients with poor insight (Insight - ), relative to patients with preserved clinical insight (Insight + ), and healthy controls. ORIGINAL ARTICLE 311 September 22, 2016|Volume 6|Issue 3| WJP|www.wjgnet.com Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.5498/wjp.v6.i3.311 World J Psychiatr 2016 September 22; 6(3): 311-321 ISSN 2220-3206 (online) © 2016 Baishideng Publishing Group Inc. All rights reserved. World Journal of Psychiatry WJP Case Control Study