309 Journal of Anesthesiology & Clinical Research https://hmpublisher.com/index.php/JACR/index Vol 3 Issue 2 2022 Immune Response and Immunobiology COVID-19 (Coronavirus Disease 2019) Rachmat Hidayat 1# , Patricia Wulandari 2 1 Department of Biology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia 2 Cattleya Mental Health Center, Palembang, Indonesia *Corresponding author: Rachmat Hidayat Department of Biology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia Email: dr.rachmat.hidayat@gmail.com ABSTRACT SARS-CoV-2 not only activates an antiviral immune response but can also cause an uncontrolled inflammatory response characterized by the marked release of proinflammatory cytokines in patients with severe COVID-19, leading to lymphopenia lymphocyte dysfunction, and granulocyte and monocyte abnormalities. The immune pattern of COVID-19 includes lymphopenia, lymphocyte activation and dysfunction, granulocyte and monocyte abnormalities, increased cytokine production, and increased antibodies. Keywords: COVID-19, SARS-CoV2, immunobiology