Int.J.Curr.Microbiol.App.Sci (2019) 8(3): 1554-1560 1554 Original Research Article https://doi.org/10.20546/ijcmas.2019.803.179 Prevalence and Clinical Manifestations of Ketosis in Cows in and Around Bikaner Mohammed Nazeer, Sandeep Kumar, Manu Jaiswal * , Alok Mishra, Grijesh Upmanyu, Pratyush Kumar and Sirigiri Ashok Kumar Faculty of Veterinary and Animal Science, Institute of Agricultural Sciences, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur, (U.P.), India *Corresponding author ABSTRACT Introduction According to livestock census (2007) Rajasthan has 1.24 crore cattle and 1.15 crore buffaloes. In that population Bikaner has 7.28 lacs cattle and 1.42 lacs buffaloes. The state produces approximately 8713 MT of milk per year, which is approximately 11 per cent of total milk production in the country. At the onset of lactation, the dairy cow must accommodate a tremendous increase in energy demand by the mammary gland for milk production. This is realized partly by increasing feed intake and partly by fat mobilization from adipose tissue. However, excessive fat mobilization can induce an imbalance in hepatic carbohydrate and fat metabolism, characterized by elevated concentrations of ketone bodies called hyperketonemia Haelst et al., (2008). Ketosis is a production disease with high intensity of prolonged morbidity causing substantial loss in dairy industry (Holmes, 1950; Radostits et al., (2010). Ketosis has become a very common metabolic disorder in modern dairy production by causing decrease in milk production and increase in prevalence and duration of fresh cow diseases, enhancing The present study was conducted to determine prevalence of ketosis in cows in and around Bikaner and clinical manifestations in ketotic cows. Based upon test results 40 cows were diagnosed as ketotic. The overall prevalence of ketosis amongst post-parturient cows was found to be 11.42 per cent, age-wise prevalence of ketosis was highest in 8-9 years of age (35 per cent) and lowest in >9 (5 per cent) years of age, parity-wise prevalence of ketosis was highest in 3 rd and 4 th parity (25 per cent) and lowest in 1 st and 6 th (5 per cent), stage of lactation-wise prevalence of ketosis was highest in 1-2 i.e. 45% and lowest in 4-5 month i.e 2.5% after parturition and month-wise prevalence of ketosis was highest in January (25 per cent) and lowest in April (13 percent). The clinical examination of these animals revealed non significant elevation in temperature and pulse rate but mild decrease in respiration rate, but there was highly significant increase (P<0.01) in ruminal movement (per two min.) and milk yield (lt. Per day) in treated cows in all groups (A, B and C). Keywords Ketosis, Prevalence, Ketone bodies, Post-parturient, Ruminal Movement Accepted: 12 February 2019 Available Online: 10 March 2019 Article Info International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 03 (2019) Journal homepage: http://www.ijcmas.com