Journal Pre-proof Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway Ahmed H. Elmenoufy, Francesco Gentile, David Jay, Feridoun Karimi-Busheri, Xiaoyan Yang, Olivier M. Soueidan, Rajam S. Mani, Gloria Ciniero, Jack A. Tuszynski, Michael Weinfeld, Frederick G. West PII: S0223-5234(20)30630-9 DOI: https://doi.org/10.1016/j.ejmech.2020.112658 Reference: EJMECH 112658 To appear in: European Journal of Medicinal Chemistry Received Date: 8 June 2020 Revised Date: 7 July 2020 Accepted Date: 8 July 2020 Please cite this article as: A.H. Elmenoufy, F. Gentile, D. Jay, F. Karimi-Busheri, X. Yang, O.M. Soueidan, R.S. Mani, G. Ciniero, J.A. Tuszynski, M. Weinfeld, F.G. West, Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway, European Journal of Medicinal Chemistry, https://doi.org/10.1016/j.ejmech.2020.112658. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Elsevier Masson SAS. All rights reserved.