Endocrinol Diabetes Nutr. 2019;66(10):647---653 www.elsevier.es/endo Endocrinología, Diabetes y Nutrición ORIGINAL ARTICLE The effect of a new mixture of sugar and sugar-alcohols compared to sucrose and glucose on blood glucose increase and the possible adverse reactions: A phase I double-blind, three-way randomized cross-over clinical trial Mohammad Ali Mohsenpour a,b , Fatemeh Kaseb c , Reza Nazemian c , Hassan Mozaffari-Khosravi a,c,d , Hossein Fallahzadeh e , Amin Salehi-Abargouei a,d,* a Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran b International Branch, Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran c Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran d Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran e Department of Biostatistics and Epidemiology, Prevention and Epidemiology of Non-Communicable Disease Research Center, Health School, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Received 21 September 2018; accepted 28 December 2018 Available online 11 March 2019 KEYWORDS Sweetener; Sugars; Sugar alcohols; Blood glucose control; Diabetes Abstract Introduction: Several sweeteners are introduced to replace sucrose in the human diet. However, they had their own limitations and concerns, particularly in terms of their taste and their long- term health consequences. This study examined the effect of a new mixture of sugars and sugar alcohol on the postprandial blood glucose levels and its possible gastrointestinal (GI) adverse reactions in human adults. Methods: In this double-blind three-way randomized clinical trial, adults (21 with type 2 dia- betes and 20 healthy) received 300 ml of three beverages containing 50 g glucose, sucrose, and lacritose (a mixture of lactose, fructose, sucrose, and erythritol) when they were in the fasted state in a random order. Postprandial serum glucose was checked every 30 min up to 2 h and the gastrointestinal reactions were collected. Results: The mean serum glucose was significantly lower in all time points after ingestion of the lacritose for participants with type 2 diabetes compared to glucose and sucrose (P < 0.05). The blood glucose levels were significantly lower in the 30th and 60th min for healthy subjects (P < 0.05). Adverse GI reactions were not significant between the test beverages. * Corresponding author. E-mail addresses: abargouei@hlth.mui.ac.ir, abargouei@gmail.com (A. Salehi-Abargouei). https://doi.org/10.1016/j.endinu.2018.12.008 2530-0164/© 2019 SEEN y SED. Published by Elsevier Espa˜ na, S.L.U. All rights reserved.