Accepted Manuscript (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocy- clic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopre- ventive agent Neill J. Horley, Kenneth J.M. Beresford, Supriya Kaduskar, Prashant Joshi, Glen J.P. McCann, Ketan C. Ruparelia, Ibidapo S. Williams, Linda Gatchie, Vinay R. Sonawane, Sandip B. Bharate, Bhabatosh Chaudhuri PII: S0960-894X(17)31085-5 DOI: https://doi.org/10.1016/j.bmcl.2017.11.009 Reference: BMCL 25415 To appear in: Bioorganic & Medicinal Chemistry Letters Received Date: 9 October 2017 Revised Date: 3 November 2017 Accepted Date: 5 November 2017 Please cite this article as: Horley, N.J., Beresford, K.J.M., Kaduskar, S., Joshi, P., McCann, G.J.P., Ruparelia, K.C., Williams, I.S., Gatchie, L., Sonawane, V.R., Bharate, S.B., Chaudhuri, B., (E)-3-(3,4,5-Trimethoxyphenyl)-1- (pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent, Bioorganic & Medicinal Chemistry Letters (2017), doi: https://doi.org/10.1016/j.bmcl. 2017.11.009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.