Indian J Physiol Pharmacol 2019; 63(2) Anti-hypertensive Effect of Okra Seeds 175 Original Article Anti-hypertensive Effect of Abelmoschus Esculentus (Okra) Seed Extracts in Fructose-induced Hypertensive Rats Kallolika Mondal*, Shivalinge Gowda K.P. and Suman Manandhar Department of Pharmacology, PES College of Pharmacy, Bengaluru – 50 Abstract The aim of this study was to investigate the protective activity of ethanolic Abelmoschus esculentus seed extract (EAESE) in fructose-induced Hypertensive rat model. Even though several synthetic drugs have been discovered to treat hypertension, it is important to observe the contribution of the daily diet in easing the hypertension and hence the possible therapeutic activity of the seeds from the fruit was studied. The rats were divided randomly into 4 groups (n=6). Group I was considered as the Normal control. Group II animals were treated with only 10% w/v Fructose solution for 6 weeks (42 days). Group III animals were treated with 10% w/v Fructose solution for 6 weeks (42 days) and EAESE (150 mg/kg bw p.o) after 3 weeks i.e. from the 22 nd day till the end of the study period (42 nd day). Group IV animals were treated with 10% w/v Fructose solution for 6 weeks (42 days) and Enalapril (10 mg/kg bw p.o) after 3 weeks i.e. from the 22 nd day till the end of the study period (42 nd day). Physiological parameters ECG, heart rate and blood pressure were measured and recorded by the invasive method and the Serum parameters: Total Cholesterol and Triglyceride were measured. Result: The ECG pattern and Heart rate was improved in the EAESE treated Hypertensive rats. Remarkable reduction in the Blood pressure [systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP)] levels were observed along with a significant reduction in the Total cholesterol and Triglyceride levels. Conclusion: From the results obtained, it can be suggested that the ethanolic extract of Abelmoschus esculentus seeds has the potential antihypertensive activity as well anti-hyperlipidaemic activity. Indian J Physiol Pharmacol 2019; 63(2) : 175–181 *Corresponding author : Kallolika Mondal, Department of Pharmacology, PES College of Pharmacy, Bengaluru – 50. Email: kallolika.1993@gmail.com (Received on Nov. 01, 2017) systemic pressure consistently above the normal range (90 to 120/60 to 80 mmHg). Clinicians now consider 125 to 139/85 to 89 mmHg to be pre- hypertension (stage before the onset of hypertension). Although hypertension often produces no symptoms, the long-term consequences may be very serious. Chronic hypertension has greatest effects on the main arteries and structure and functioning of heart. Chronic hypertension has its greatest effects on the Introduction Hypertension is high blood pressure, that is, a resting