Indian Journal of Pharmaceutical Education and Research | Vol 55 | Issue 4 | Oct-Dec, 2021 989 Original Artcle www.ijper.org BioFibGel: A Green Nanotechnology Based Wound Dressing Garima Shandilya 1 , Kirtan Tarwadi 1 , Sachin Chavan 1, *, Jai Singh Vaghela 2 1 Bharati Vidhyapeeth (Deemed to be University), College of Engineering, Pune, Maharashtra, INDIA. 2 Department of Pharmacy, Bhupal Nobles University, College of Pharmacy, Udaipur, Rajasthan, INDIA. ABSTRACT Aim: Wound is a fragile and complex injury which can be as simple as a minor cut to the deep lesions and traumatic gash. Depending on the patient’s internal and external conditions, wounds can progress backward or forward. Acute hemorrhage and wound infections are the main cause of loss of life in critical conditions of war feld or in traumatic accidents. Innovation: BioFibGel bandage/dressing is a green nanotechnology based wound care product which is intended to be used in trauma, combat injuries (bleeding gunshot wounds) and mangling as frst-line emergency tool. The dressing can absorb and retain signifcant amount of water without dissolving or losing their structure, stabilize blood fow and avert bleeding. Materials and Results: BioFibGel is silver nanoparticles based hydrogel sheets/ fbers made up of gelatin, glycerin and aloe vera which are considered as ideal materials for hemostasis activities and encourages cleaning and protection from reinjures or infection and speeds wound healing along with real-time monitoring of pH of wound using carbon dots fuorescence. Conclusion: This work is an attempt to devise a wound dressing that can aid in natural blood-clotting mechanism (sparing blood loss) and providing positive environment in wound healing. Key words: Wound, Haemorrhage, Green nanotechnology, Silver nanoparticles, Wound dressing, Carbon dots. DOI: 10.5530/ijper.55.4.199 Correspondence: Dr. Sachin Chavan Bharati Vidhyapeeth Deemed to be University, College of Engineering,Pune-411043, Maharashtra, INDIA. Phone: +91-9271635407, Email: sschavan@bvucoep. edu.in Submission Date: 17-04-2021; Revision Date: 06-07-2021; Accepted Date: 24-08-2021 INTRODUCTION A wound dressing is aseptic covering provided to the wound to ensure fast and effective healing, reduce infection, scar or further harm. Dressings are intended to supply skin abrasion a sterile, breathable and moist conditions facilitating epithelial- ization and regeneration. These protective layers between wound bed and dressings forms an intermediate to acclimate optimum healing states throughout the way time of dressing. Diverse wound dressings are avail- able in the markets which are differently applicable on different wounds. The right dressing could make a big difference in properly treating the wound. Commercially available wound dressing materials such as hydrogels, films, nanopar- ticles incorporated dressings, hydrofiber, alginates and cellulose- hydrocolloids have been investigated and shown proven results in wound healing. Increasing interest for nanotechnology applications in medicine and wound care has revolutionized non- theoretical wound management. Nanotechnology being means to overcome cellular or subcellular dimensions has acquired a special place in wound therapies by intro- ducing innovative nanosystems and products in form of drug carriers, targeting agents, scaffolds as well as regeneration factors. BioFibGel is such an example of nanosystem in wound therapeutics. BioFibGel is a green nanotechnology based wound dressing with biologically synthesized silver nanopar- ticles subsumed in gelatin-based hydrofibers/ gel with aim to be used as haemostatic crises savior as well as dressing for wound management. This paper describes about BioFibGel concept, formulation and its performance for wound therapeutics.