Research Article Strategies to Improvise Organ Donor Pool: A Study on the Knowledge, Attitudes, and Performance of Higher Secondary School Teachers Towards the Organ Donation Krishnaraju Venkatesan , 1 Durgaramani Sivadasan, 2 Neelaveni Thangavel, 3 Shadia Hamoud Alshahrani , 4 Premalatha Paulsamy, 4 Kandasamy Muthugounder , 5 Kousalya Prabahar , 6 Gamal Osman Elhassan, 7 Kalpana Krishnaraju, 8,9 Sirajudeen SheikhAlavudeen, 10 Kumar Venkatesan, 11 and Kenenisa Dekeba 12 1 Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir, Saudi Arabia 2 Department of Pharmaceutics, College of Pharmacy, Jazan University, Jizan, Saudi Arabia 3 Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jizan, Saudi Arabia 4 College of Nursing, Mahalah Branch for Girls King Khalid University, Asir, Saudi Arabia 5 Dharan Nursing College, Salem, Tamilnadu, India 6 Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk-71491, P .O. Box-741, Saudi Arabia 7 Department of Pharmaceutics, Unaizah College of Pharmacy, Qassim University, Alqassim, KSA, Saudi Arabia 8 Department of Pharmaceutical Chemistry &Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, India 9 Department of Pharmaceutics, Faculty of Pharmacy, Omdruman Islamic University, Omdurman, Khartoum, Sudan 10 Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia 11 Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Asir-Abha, Saudi Arabia 61421 12 Department of Food Process Engineering, College of Engineering and Technology, Wolkite University, Wolkite, Ethiopia Correspondence should be addressed to Krishnaraju Venkatesan; kvenkatesan@kku.edu.sa and Kenenisa Dekeba; kenenisa.dekeba@wku.edu.et Received 19 January 2022; Accepted 22 March 2022; Published 28 June 2022 Academic Editor: Yuvaraja Teekaraman Copyright © 2022 Krishnaraju Venkatesan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. This study aimed to assess higher secondary school teachers’ knowledge, attitude, and performance levels towards organ transplantation and donation (OTD). Teachers have an essential role in giving knowledge to children and teenagers, and they can influence their views. Organ transplantation offers re-life to many patients, yet organ shortages are a global issue. Teachers who influence students’ future attitudes regarding organ donation must have a favorable attitude and genuine knowledge. Materials and Methods. The research method was descriptive and cross-sectional. The sample size was 372 school teachers in Villupuram district of Tamilnadu, India, selected using a convenient sampling method. A survey questionnaire was used to assess the knowledge and attitude about OTD, the reason for donating/not donating organs. Multivariate analysis was performed to identify critical variables affecting intent to practice. Results. The teachers’ mean scores with SD on knowledge, attitude, and performance were 7:61 ± 2:74, 8:81 ± 2:08, and 0:38 ± 0:11, respectively. The linear regression analysis showed that the knowledge (p <0:001) and attitude (p <0:05) of the participants were positively associated with organ donation performance. A significant relationship was also observed between gender (p <0:036), age (p <0:01), and education status (p <0:001) with the performance of the teachers. Lack of family support was the most spelt reason for unwillingness for organ donation. Conclusion. The positive linear correlations underline that having more information may lead to a more optimistic mindset and, as a result, to better practices. Teachers should be provided with overall health teaching campaigns to increase the number of possible organ donors. Teachers serve as role models for students, families, and society by changing their attitudes. Hindawi BioMed Research International Volume 2022, Article ID 5438492, 8 pages https://doi.org/10.1155/2022/5438492