ORIGINAL ARTICLE Effects of Chronic Care Model-based interventions on self-management, quality of life and patient satisfaction in patients with ischemic stroke: A single-blinded randomized controlled trial Simge Kalav 1 | Hicran Bektas 2 | Ali Ünal 3 1 Faculty of Nursing, Department of Internal Medicine Nursing, Aydin Adnan Menderes University, Aydin, Turkey 2 Faculty of Nursing, Department of Internal Medicine Nursing, Akdeniz University, Antalya, Turkey 3 Neurology Department, Akdeniz University School of Medicine, Antalya, Turkey Correspondence Simge Kalav, Faculty of Nursing, Department of Internal Medicine Nursing, Adnan Menderes University, Campus, 09100, Aydın, Turkey. Email: simge.kalav@gmail.com Funding information Akdeniz University Scientific Research Projects Coordination Unit, Grant/Award Number: TDK-2018-3584 Abstract Aim: This study was designed to evaluate the effect of Chronic Care Model (CCM)-based interventions on primary outcomes (self-efficacy, quality of life/ QoL, patient satisfaction) and secondary outcomes (activities of daily living/ ADL, metabolic control variables, stroke knowledge level, healthy eating habits, physical activity, taking regular medication, measuring blood pressure regularly, living in harmony with the disease, outcomes regarding telephone interviews) in patients with ischemic stroke. Method: The intervention group (IG) received a 12-week StrokeCARE inter- vention protocol based on the four components of the CCM. The control group (CG) received only routine patient care. Changes between scores at two time points regarding self-efficacy, QoL, ADL, and metabolic control variables were calculated for each group, and then the mean changes were compared between the two groups. Results: The mean ages of the patients were 55.9 ± 11.44 and 58.9 ± 13.82 years (respectively IG; CG), and 64.7% of the patients were male in both groups. Most patients had other chronic diseases accompanying ischemic stroke. No significant differences were found between the two groups with respect to self-efficacy and QoL. Patient satisfaction was significantly higher in the IG. Positive feedback percentages of the patients in the IG regarding stroke knowledge level and consuming whole-grain food at the end of the 12 weeks increased significantly. This protocol had no significant effects on the second- ary outcomes. Conclusion: The CCM-based interventions may increase the satisfaction level of the patients and help to raise awareness of the risk of a secondary stroke. More studies are needed to examine the effects of these interventions (ClinicalTrials.gov-Identifier Number:NCT04161820). KEYWORDS Chronic Care Model, health education, quality of life, self-management, stroke Received: 27 January 2021 Revised: 23 April 2021 Accepted: 6 June 2021 DOI: 10.1111/jjns.12441 Jpn J Nurs Sci. 2021;e12441. wileyonlinelibrary.com/journal/jjns © 2021 Japan Academy of Nursing Science. 1 of 18 https://doi.org/10.1111/jjns.12441