Recent synthetic aspects on the chemistry of aminocoumarins Wafaa S. Hamama 1 • Mona E. Ibrahim 1 • Asmaa E. Metwalli 1 • Hanafi H. Zoorob 1 Received: 10 February 2017 / Accepted: 2 May 2017 Ó Springer Science+Business Media Dordrecht 2017 Abstract Coumarin and their derivatives are important groups of heterocyclic com- pounds. They have attracted considerable interest because of their great biological importance. This review describes the work on the synthesis and heterocyclization reactions of aminocoumarines. It was found that the cyclocondensation process depen- ded mainly on the chemoselective and regioselectivity states of the enamino skeleton. Graphical Abstract Synthetic methods O O R NH 2 O NH 2 O R Chemical Reactivity O O NHR O O Me Me Me O O N COOEt R O O O HN HO OH O NH Me O O O NH O Ph O R O O N N N HO R Keywords Coumarines Á Enamine Á Synthesis and biological importance & Wafaa S. Hamama wshamama53@gmail.com; wshamama@yahoo.com 1 Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt 123 Res Chem Intermed DOI 10.1007/s11164-017-2973-9