A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous 1 challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters 2 3 Kathryn McGuckin Wuertz 1 , Erica K. Barkei 2 , Wei-Hung Chen 3,4 , Elizabeth J. Martinez 3,4 , Ines 4 Lakhal-Naouar 4,5 , Linda L. Jagodzinski 5 , Dominic Paquin-Proulx 1,4 , Gregory D. Gromowski 6 , 5 Isabella Swafford 1,4 , Akshaya Ganesh 1,7 , Ming Dong 1,4 , Xiankun Zeng 8 , Paul V. Thomas 3,4 , 6 Rajeshwer S. Sankhala 3,4 , Agnes Hajduczki 3,4 , Caroline E. Peterson 3,4 , Caitlin Kuklis 6 , Sandrine 7 Soman 6 , Lindsay Wieczorek 1,4 , Michelle Zemil 1,4 , Alexander Anderson 3,7 , Janice Darden 4,5 , 8 Heather Hernandez 4,5 , Hannah Grove 4,5 , Vincent Dussupt 1,4 , Holly Hack 4,5 , Rafael de la Barrera 9 , 9 Stasya Zarling 9 , James F. Wood 9 , Jeffrey W. Froude 9 , Matthew Gagne 10 , Amy R. Henry 10 , Elham 10 Bayat Mokhtari 11 , Prakriti Mudvari 11 , Shelly J. Krebs 1,4 , Andrew S. Pekosz 12 , Jeffrey R. Currier 6 , 11 Swagata Kar 13 , Maciel Porto 13 , Adrienne Winn 13 , Kamil Radzyminski 13 , Mark G. Lewis 13 , Sandhya 12 Vasan 4 , Mehul Suthar 14 , Victoria R. Polonis 1 , Gary R. Matyas 1 , Eli A. Boritz 11 , Daniel C. Douek 10 , 13 Robert A. Seder 15 , Sharon P. Daye 16 , Mangala Rao 1 , Sheila A. Peel 5 , M. Gordon Joyce 3,4,18 , Diane 14 L. Bolton 1,4,18 , Nelson L. Michael 17,18,* and Kayvon Modjarrad 3,18,* 15 16 1 U.S. Military HIV Research Program, Center for Infectious Diseases Research, Walter Reed Army Institute of 17 Research, Silver Spring, Maryland USA 18 2 Veterinary Pathology Division, Walter Reed Army Institute of Research, Silver Spring, Maryland USA 19 3 Emerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of 20 Research, Silver Spring, Maryland USA 21 4 Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland USA 22 105 and is also made available for use under a CC0 license. (which was not certified by peer review) is the author/funder. This article is a US Government work. It is not subject to copyright under 17 USC The copyright holder for this preprint this version posted June 16, 2021. ; https://doi.org/10.1101/2021.06.16.448525 doi: bioRxiv preprint