How to Cite: Khalil, A. I., Elgamal, S. A., & Naser, R. E. (2022). The relationship between diabetes mellitus, psychological stressors and COVID-19 challenges and managements: An evidence-based literature review. International Journal of Health Sciences, 6(S5), 10383–10407. https://doi.org/10.53730/ijhs.v6nS5.12037 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 9 April 2022, Manuscript revised: 18 June 2022, Accepted for publication: 27 July 2022 10383 The relationship between diabetes mellitus, psychological stressors and COVID-19 challenges and managements: An evidence- based literature review Amal I. Khalil Prof of Psychiatry and Mental Health Nursing, Menoufia University, Egypt and Assistant Professor Critical Care and Emergency Nursing, College of Nursing, King Saud Bin Abdualaziz University for Health Sciences, College of Nursing, Jeddah Saudi Arabia Corresponding author email: Amalkhalil34@yahoo.com Seham A. Elgamal Assistant Professor Critical Care and Emergency Nursing, College of Nursing, King Saud Bin Abdualaziz University for Health Sciences, College of Nursing, Jeddah Saudi Arabia Rawan E. Naser Faculty of Medicine, Tanta University Abstract---Background: COVID-19 outbreak is likely to cause psychological problems, such as anxiety, depression, and stress; which may negatively influence one's glycemic control. The pandemic could increase the prevalence and change in nature of diabetes among people living in countries affected by it. The aim of this review is to clarify the blurred areas and types of relationship between diabetes, psychiatric disorders, and COVID-19 pandemic. Methods: Literature reviews and evidence-based researches were studied using PubMed and Google Scholar for the following keywords: "COVID-19", "SARS- CoV-2", "diabetes", "epidemiology", "pathophysiology", "ACE2", "manifestation”, “immune system”, “link between diabetes and psychiatric illnesses”, and "treatment with antipsychotics and antidepressants”. Results revealed that there is a casual mutual relationship between DM and psychiatric disorders. Furthermore, there is a bidirectional relationship between DM and the vulnerability of acquiring COVID-19 infection. Additionally, DM and SARS-CoV-2 infection worsen each other, thus, diabetics are more likely to develop severe COVID-19. Conclusion and Recommendation: It is recommended that physicians and health care providers counsel their