International Journal of Pharmaceutical and Bio-Medical Science ISSN(print): 2767-827X, ISSN(online): 2767-830X Volume 02 Issue 05 May 2022 Page No: 109-115 DOI: https://doi.org/10.47191/ijpbms/v2-i5-05, Impact Factor: 5.374 109 Volume 02 Issue 05 May 2022 Corresponding Author: Mr. Utkalendu Suvendusekhar Samantaray “FLAG” Tag Sequenced E-Protein Marker Demonstrating Tetravalent Dengue Virus Like Particles (DENV-Lps) As Potential Vaccine Candidate Mr. Utkalendu Suvendusekhar Samantaray 1 , Ms. Rutupurna Satapathy 2 1 MSc Utkal University, Bhubaneswar, Odisha, INDIA 2 Msc KIIT University, Bhubaneswar, Odisha, INDIA INTRODUCTION Dengue is a very deadly virus. It causes viral infections that are transmitted to humans through a small bite of specific mosquitoes. These mosquitoes are generally infected. The main primary vector of this deadly disease is Aedes aegypti mosquitoes. This virus is generally called the dengue virus or DENV. It is a single-stranded RNA virus. Due to this dengue virus causes deadly and hazardous infections. It mainly occurs in various tropical and subtropical regions. Dengue causes a very broad range of diseases, sometimes making the detection of symptoms quite hard. There are numerous causes that are directly and indirectly linked to the growth of the dengue virus in the environment. The symptoms may vary from simple flu to deadly fever. And till date, there is no specific treatment for dengue. In many countries especially the tropical regions, there has been a huge number of deaths from this DENV virus. The complicated pathogenesis of this deadly virus has been a constant barrier for scientists to discover a medicine or vaccine for this disease. Dengue virus falls under the family of Flaviviridae. It has four different types of serotypes present in it. Those are DENV-1, DENV-2, DENV-3, and DENV-4. The epidemiological patterns of these four serotypes are interlinked with each other. They can co-circulate among each other and can create severe to very severe infections. The most depictful nature of DENV is that it transmits from one person to another by various means. Though it is quite rare it is possible of creating local transmissions. The dengue virus has a very rough kind of structure. The microscopic structure clearly shows how the dengue virus can replicate inside a host organism. The structure consists of various viral genomes which are covered by an envelope and shelled by a couple of proteins. And the genome is made up ABSTRACT ARTICLE DETAILS Dengue is a very deadly virus. It causes viral infections that are transmitted to humans through a small bite of specific mosquitoes. These mosquitoes are generally infected. The main primary vector of this deadly disease is Aedes aegypti mosquitoes. This virus is generally called the dengue virus or DENV. It is a single-stranded RNA virus. Due to this dengue virus causes deadly and hazardous infections. It mainly occurs in various tropical and subtropical regions. Dengue causes a very broad range of diseases, sometimes making the detection of symptoms quite hard. There are numerous causes that are directly and indirectly linked to the growth of the dengue virus in the environment. The symptoms may vary from simple flu to deadly fever. And till date, there is no specific treatment for dengue. In many countries especially the tropical regions, there has been a huge number of deaths from this DENV virus. The complicated pathogenesis of this deadly virus has been a constant barrier for scientists to discover a medicine or vaccine for this disease. Dengue virus falls under the family of Flaviviridae. It has four different types of serotypes present in it. Those are DENV-1, DENV-2, DENV-3, and DENV-4. The epidemiological patterns of these four serotypes are interlinked with each other. They can co-circulate among each other and can create severe to very severe infections. The most respectful nature of DENV is that it transmits from one person to another by various means. Though it is quite rare it is possible of creating local transmissions. KEY WORDS: DENV, Dengue, Virus like particles, Vaccine Published On: 31 May 2022 Available on: https://ijpbms.com/